宫腔灌注富血小板血浆联合定坤丹治疗薄型子宫内膜效果研究
Effect of intrauterine infusion of platelet rich plasma combined with Dingkundan in the treatment of thin endometrium
陈苑 1兰鹰 1雷晓妮1
作者信息
- 1. 545002 广西 柳州,广西科技大学第一附属医院妇科
- 折叠
摘要
目的 探究宫腔灌注富血小板血浆(platelet rich plasma,PRP)联合定坤丹治疗薄型子宫内膜的效果.方法 选择2020 年1 月至2022 年1 月广西科技大学第一附属医院收治的90 例薄型子宫内膜患者,采用随机数字表法将患者分为3 组,宫腔灌注PRP组(30 例)、定坤丹组(30 例)、联合组(30 例),宫腔灌注PRP组采用宫腔灌注PRP治疗,定坤丹组采用定坤丹治疗,联合组采用宫腔灌注PRP联合定坤丹治疗,比较3 组患者治疗前后的子宫动脉、子宫内膜螺旋动脉阻力指数等血流参数水平、子宫内膜厚度和形态、月经血量、血清指标、临床妊娠情况及并发症发生率.结果 治疗后,联合组患者子宫动脉、子宫内膜螺旋动脉阻力指数等血流参数水平低于宫腔灌注PRP组、定坤丹组,子宫内膜厚度大于宫腔灌注PRP组、定坤丹组(P<0.05),联合组患者子宫内膜形态A型占比、月经血量、血清指标(PDGF-AB、PDGF-BB、TGF-β、VEGFA)水平、妊娠成功率高于宫腔灌注PRP组、定坤丹组,差异均有统计学意义(P<0.05);3 组并发症总发生率比较,差异无统计学意义(P>0.05).结论 宫腔灌注PRP联合定坤丹治疗薄型子宫内膜效果显著,不仅能有效改善患者子宫内膜血流和形态,还能提高其子宫内膜厚度,促进血管新生和修复,从而提高其妊娠成功率,安全性高,值得临床应用和推广.
Abstract
Objective To explore the effect of intrauterine infusion of platelet-rich plasma(PRP)combined with Dingkundan in the treatment of thin endometrium.Methods From January 2020 to January 2022,90 patients with thin endometrium admitted to the First Affiliated Hospital of Guangxi University of Science and Technology were selected,and the patients were divided into 3 groups by random number table method,uterine perfusion PRP group(30 cases),Dingkundan group(30 cases),combined group(30 cases),uterine perfusion PRP group was treated with uterine perfusion PRP,Dingkundan group was treated with Dingkundan,and the combined group was treated with intrauterine perfusion PRP combined with Dingkundan.The levels of blood flow parameters of uterine artery and endometrial spiral artery resistance index,endometrial thickness and morphology,menstrual blood volume,serum index,clinical pregnancy and complication rates before and after treatment were compared between the three groups.Results After treatment,the levels of blood flow parameters of uterine artery and endometrial spiral artery resistance index in the combined group were lower than those of uterine perfusion PRP group and Dingkuntan group,endometrial thickness was higher than uterine perfusion PRP group and Dingkuntan group(P<0.05).The proportion of endometrial morphology type A,menstrual blood volume,and serum indicators(PDGF-AB,PDGF-BB,TGF,VEGFA),pregnancy success rate in the combined group were higher than those of the uterine perfusion PRP group and Dingkundan group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of complications among the three groups(P>0.05).Conclusion Intrauterine infusion of PRP combined with Dingkundan is effective in the treatment of thin endometrium,which can not only effectively improve the endometrial blood flow and morphology of patients,but also improve the endometrial thickness and promote angiogenesis and repair,thereby increasing the success rate of pregnancy.It has high safety and is worthy of clinical application and promotion.
关键词
宫腔灌注/富血小板/定坤丹/薄型子宫内膜/子宫内膜容受性Key words
intrauterine infusion/platelet rich plasma/Dingkun pill/thin endometrium/endometrial receptivity引用本文复制引用
基金项目
广西壮族自治区医疗卫生适宜技术开发与推广应用项目(S2019004)
出版年
2024
NETL
NSTL
万方数据