Clinical observation of different doses of mifepristone combined with Mirena after adenomyosis lesion resection
Objective To explore the clinical effect of different doses of mifepristone orally combined with intrauterine placement of Mirena after adenomyosis lesion resection.Methods 80 patients with adenomyosis treated in the Department of Obstetrics and Gynecology of Xuancheng City Central Hospital of Anhui Province from September 2019 to September 2022 were selected as the study subjects.They were randomly divided into control group and observation group with 40 cases in each group.The control group was treated with normal dose of mifepristone orally(10 mg/d)combined with intrauterine placement of Mirena after operation,while the observation group was treated with low dose of mifepristone orally(5 mg/d)combined with intrauterine placement of Mirena after operation.The menstrual volume,uterine volume,degree of dysmenorrhea,tumor marker index,hemoglobin(Hb),ovarian function and incidence of adverse reactions were compared between the two groups.Results Compared with before treatment,both groups showed a decrease in visual analogue scale(VAS)scores,uterine volume and menstrual volume,levels of estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH),serum carbohydrate antigen 125(CA125),and increased levels of hemoglobin(Hb)(P<0.05).After 3 months of treatment,there were no statistically significant difference in VAS scores,uterine volume,menstrual volume,E2,LH,FSH,CA125,and Hb levels between the two groups(P>0.05).The incidence of adverse reactions in the observation group(5.00%)was lower than that in the control group(20.00%)(P<0.05).Conclusion After the resection of adenomyosis,the application of intrauterine placement of Mirena combined with normal dose and low dose mifepristone oral treatment can effectively improve the ovarian function,dysmenorrhea and anemia symptoms of patients,and promote the uterine volume and menstrual volume to return to normal,but the combination of low dose mifepristone oral treatment is relatively safe.
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