Expression of TRIM59 and CCNE1 in cervical cancer tissues and their relationship with prognosis
Objective To explore the expression of tripartite motif-59(TRIM59)and cyclin E1(CCNE1)in cervical cancer tissues and their relationship with the prognosis of cervical cancer patients.Methods A total of 120 patients with cervical cancer who were admitted to Dalian Women and Children Medical Center(Group)from January 2015 to January 2017 were selected.The cancer tissues and adjacent tissues were taken intraoperatively as the observation group and the control group respectively.The expression of TRIM59 and CCNE1 was determined by immunohistochemistry.Kaplan-Meier method was used to analyze the relationship between the expression of TRIM59 and CCNE1 and the prognosis of patients;and multivariate COX regression analysis was used to analyze the risk factors affecting the prognosis of cervical cancer patients.Results The positive expression rates of TRIM59 and CCNE1 in the observation group were higher than those in the control group(P<0.05).The expression of TRIM59 and CCNE1 in cervical cancer patients was not related to patient age,tumor diameter and pathological type(P>0.05),but was related to TNM stage,differentiation degree and lymph node metastasis(P<0.05).Kaplan-Meier survival curve analysis showed that the survival rate of cervical cancer patients with TRIM59 positive expression group was lower than that of negative expression group(χ2 = 4.901,P = 0.027);the survival rate of CCNE1 positive expression group was lower than that of negative expression group(χ2 =5.583,P =0.018).TRIM59 positive expression,CCNE1 positive expression,lymph node metastasis,poorly differentiated,TNM stage(Ⅱa)were risk factors for poor prognosis in cervical cancer patients(P<0.05).Conclusion The expression of TRIM59 and CCNE1 in cervical cancer tissues is abnormally increased,both are risk factors for poor prognosis in patients with cervical cancer.
万方数据
维普
