Value of colposcopy negative quadrant biopsy combined with high-risk HPV mRNA in diagnosis of cervical cancer
Objective To explore the value of colposcopy negative quadrant biopsy combined with high-risk HPV mRNA in the diagnosis of cervical cancer,and analyze its consistency with pathological diagnosis.Methods A total of 122 patients with suspected cervical cancer in Taiyuan People's Hospital from October 2020 to October 2022 were included.All patients underwent colposcopy negative quadrant biopsy and high-risk HPV mRNA examination.Taking histopathological diagnosis as the gold standard,to explore its significance in the diagnosis of cervical cancer.Results Histopathological examination showed that98 cases(80.33%)were positive in 122 suspected cervical cancer patients,including 31 cases of low-grade squamous intraepithelial lesions,41 cases of high-grade squamous intraepithelial lesions and 26 cases of squamous cell carcinoma,24 cases were negative(19.67%);taking histopathological examination results as the gold standard,the sensitivity of colposcopy negative quadrant biopsy combined with high-risk HPV mRNA in the diagnosis of cervical cancer was higher than that of single examination(P<0.05).The receiver's operating characteristic curve(ROC)showed that the AUC of colposcopy negative quadrant biopsy and high-risk HPV mRNA examination in the diagnosis of cervical cancer alone were 0.726 and 0.710,which had certain diagnostic value,but the combined diagnostic value was higher(AUC = 0.818).The consistency between colposcopy negative quadrant biopsy and high-risk HPV mRNA alone with pathological examination in diagnosing cervical lesions was ideal(Kappa = 0.719,0.658,P<0.05),and the consistency between colposcopy negative quadrant biopsy combined with high-risk HPV mRNA and histopathological examination in diagnosing cervical lesions was excellent(Kappa =0.797,P<0.05).Conclusion Colposcopy negative quadrant biopsy combined with high-risk HPV mRNA has high diagnostic value for cervical cancer,which is helpful to find more cervical lesions and can be used as an effective means for cervical cancer screening.
cervical cancercolposcopy negative quadrant biopsyhigh-risk human papillomavirus mRNApathological diagnosis
万方数据
维普
