The reationship between the expression of serum NLR,Apelin and HE4 in endometrial carcinoma and clinical features and its diagnostic value analysis
Objective To investigate the expression of neutrophil-lymphocyte ratio(NLR),Apelin and human epididymis protein 4(HE4)in endometrial carcinoma and its influencing factors.Methods The clinical data of 120 patients with suspected endometrial lesions admitted to the Shanxi Fenyang Hospital from March 2021 to March 2023 were selected for retrospective study;96 patients were diagnosed as benign lesions by pathological examination were inciuded in the benign lesion group and 24 patients of endometrial cancer were included in the endometrial cancer group.The differences of NLR,Apelin,HE4 levels between two groups,the infiuencing factors of endometrial cancer were analyzed,and analyzed the relationship between NLR,Apelin,HE4 and clinical pathological features of endometrial cancer;the value of NLR,Apelin,HE4 and combined data in diagnosis of ebdometrial cancer was analyzed by ROC curve.Results NLR,Apelin,and HE4 were higher in endometrial cancer group than in benign lesions group(P<0.05).Binary Logistic regression analysis showed that combined diabetes mellitus,abnormal endometrial echo,menopause length,endometrial thickness,NLR,Apelin,and HE4 were all risk factors for endometrial cancer development(P<0.05).NLR,Apelin,and HE4 were not associated with age,hyperlipidemia,hypertension,menopausal status,and vascular space involvement(P>0.05),but all were associated with diabetes,histological classification,cervical involvement,and depth of invasion(P<0.05).ROC curve analysis showed that AUC for NLR,Apelin and HE4 were 0.785,0.765 and 0.786,respectively;diagnostic sensitivity and specificity:NLR were 54.2%and 100.0%;Apelin were 50.0%and 95.8%;HE4 were 50.0%and 100.0%.The AUC of combined data in the diagnosis of endometrial cancer was 0.832,the sensitivity was 74.2%and specificity was 95.8%.Conclusion NLR,Apelin and HE4 are highly expressed in the serum of endometrial cancer,and are closely related to the clinical features of endometrial cancer,so they can be used to diagnose endometrial cancer,and the combined diagnosis is more accurate.However,diabetes,abnormal endometrial echo,menopause length,endometrial thickness,NLR,Apelin and HE4 are all risk factors for endometrial cancer.
endometrial cancerneutrophi-lymphocyte ratioApelinhuman epididymal protein 4expressinfluencing factor
万方数据
维普
