Efficacy and safety analysis of high intensity focused ultrasound combined with GnRH-a in the treatment of≥4 cm adenomyoma
Objective To investigate the efficacy and safety of high intensity focused ultrasound combined with gonadotropin-releasing hormone agonist(GnRH-a)in the treatment of≥4 cm adenomyoma.Methods 96 patients with adenomyoma≥4 cm from the First Affiliated Hospital of Xinjiang Medical University and Xinjiang Uygur Autonomous Region People's Hospital from June 2020 to June 2022 were selected as the study objects,and were divided into group A,group B and combination group according to random number table method,with 32 cases in each group.Group A was treated with high intensity focused ultrasound,group B was treated with GnRH-a,and the combined group was treated with high intensity focused ultrasound combined with GnRH-a.The lesion volume,matrix menstrual volume score,dysmenorrhea score,serum tumor antigen 125(CA125),vascular endothelial growth factor(VEGF)and metallomatrix proteinase-9(MMP-9)levels were compared before treatment and 3,6 and 12 months after treatment in 3 groups,and the complications were statistically analyzed.Results Before treatment,there was no statistically significant difference in lesion volume,menstrual volume score,dysmenorrhea score,serum CA125,VEGF and MMP-9 levels among the three groups(P>0.05).After 3 months,6 months,and 12 months of treatment,lesion volume,menstrual volume score,dysmenorrhea score,serum CA125,VEGF and MMP-9 levels in the three groups decreased,and the combined group was lower than group A and group B,with statistically significant differences(P<0.05).None of the patients had serious treatment-related complications.Conclusion In the treatment of patients with≥4 cm adenomyoma,high intensity focused ultrasound combined with GnRH-a can more effectively reduce lesion volume,alleviate clinical symptoms,reduce serum VEGF and MMP-9 levels,improve treatment efficiency and with high safety.
high intensity focused ultrasoundgonadotropin releasing hormone-agonistsadenomyoma
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