首页|遵循月经周期应用米非司酮联合米索前列醇治疗人流不全的临床疗效研究

遵循月经周期应用米非司酮联合米索前列醇治疗人流不全的临床疗效研究

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目的 探讨米非司酮联合米索前列醇治疗人流不全的有效性和安全性.方法 选取重庆市红十字会医院2021 年1 月至2023 年5 月符合入选标准的78 例人流不全患者,根据治疗方式分为药物治疗组(39例)和清宫组(39 例).药物治疗组即时给予米非司酮50 mg q12h口服3d,待月经来潮时给予米索前列醇 0.2 mg q12h 舌下含服 3d.清宫组患者即时行清宫术,术后常规口服抗生素 2d.比较两组的临床疗效.结果 药物治疗组和清宫组患者治愈率分别为82.05%和 84.62%,差异无统计学意义(P>0.05).药物治疗组和清宫组在月经恢复延迟(2.56%vs.17.95%)、月经流量减少(5.13%vs.25.64%)方面差异有统计学意义(P<0.05).药物治疗组和清宫组治疗后子宫粘连发生率(2.56%vs.12.82%)、继发感染发生率(2.56%vs.7.69%),差异无统计学意义(P>0.05).结论 遵循月经周期应用米非司酮联合米索前列醇可成功治疗人流不全,其治愈率与再次清宫相似,且可明显减少再次清宫术导致的子宫内膜受损.
Clinical observation of mifepristone combined with misoprostol in the treatment of incomplete abortion following menstrual cycle
Objective To investigate the efficacy and safety of mifepristone combined with misoprostol in the treatment of incomplete abortion.Methods Totally 78 patients with incomplete abortion who met the study inclusion criteria in Chongqing Red Cross Hospital from January 2021 to May 2023 were divided into drug treatment group(n=39)and curettage group(n=39).The drug treatment group received oral mifepristone 50 mg every 12 hours for 3 days at the time of diagnosis,followed by sublingual misoprostol 0.2 mg every 12 hours for 3 days when menstruation occurred.The curettage group underwent curettage surgery at the time of diagnosis and received oral antibiotics for 2 days after the operation.Compared the clinical effect of two groups.Results The cure rate of drug treatment group and curettage group was 82.05%and 84.62%,with no statistical difference(P>0.05).There was a statistically significant difference between drug treatment group and curettage group regarding delayed resumption of menstruation(2.56%vs.17.95%),decreased menstrual flow(5.13%vs.25.64%)(P<0.05).There was no significant difference in the incidence of uterine adhesions(2.56%vs.12.82%)and secondary infection(2.56%vs.7.69%)between drug treatment group and the curettage group(P>0.05).Conclusion The combination therapy of mifepristone and misoprostol following the menstrual cycle can successfully treat incomplete abortion,achieving a similar cure rate to repeat curettage while significantly reducing damage to endometrium caused by repeated curettage procedures.

incomplete abortionmifepristonemisoprostolcurettage

陈萃、董世庆、周敏

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400020 重庆,重庆市红十字会医院(江北区人民医院)妇科

人流不全 米非司酮 米索前列醇 清宫

重庆市江北区科卫联合医学项目(2023)

2024

中国计划生育和妇产科
中国医师协会 四川省医学情报研究所

中国计划生育和妇产科

CSTPCD
影响因子:1.116
ISSN:1674-4020
年,卷(期):2024.16(5)