Clinical observation of mifepristone combined with misoprostol in the treatment of incomplete abortion following menstrual cycle
Objective To investigate the efficacy and safety of mifepristone combined with misoprostol in the treatment of incomplete abortion.Methods Totally 78 patients with incomplete abortion who met the study inclusion criteria in Chongqing Red Cross Hospital from January 2021 to May 2023 were divided into drug treatment group(n=39)and curettage group(n=39).The drug treatment group received oral mifepristone 50 mg every 12 hours for 3 days at the time of diagnosis,followed by sublingual misoprostol 0.2 mg every 12 hours for 3 days when menstruation occurred.The curettage group underwent curettage surgery at the time of diagnosis and received oral antibiotics for 2 days after the operation.Compared the clinical effect of two groups.Results The cure rate of drug treatment group and curettage group was 82.05%and 84.62%,with no statistical difference(P>0.05).There was a statistically significant difference between drug treatment group and curettage group regarding delayed resumption of menstruation(2.56%vs.17.95%),decreased menstrual flow(5.13%vs.25.64%)(P<0.05).There was no significant difference in the incidence of uterine adhesions(2.56%vs.12.82%)and secondary infection(2.56%vs.7.69%)between drug treatment group and the curettage group(P>0.05).Conclusion The combination therapy of mifepristone and misoprostol following the menstrual cycle can successfully treat incomplete abortion,achieving a similar cure rate to repeat curettage while significantly reducing damage to endometrium caused by repeated curettage procedures.