Analysis of vaspin and KLK7 expression levels and their correlation with insulin resistance in polycystic ovary syndrome
Objective The expression levels of adipokine human visceral fat-specific serine protease inhibitor(vaspin)and human kallikrein related peptidase 7(KLK7)in the patients with polycystic ovary syndrome(PCOS)were examined.Compared the differential expression of vaspin and KLK7 in the serum between PCOS patients and non-PCOS patients,and the correlation between vaspin and KLK7 and insulin resistance(IR)was analyzed.Methods Selected 94 PCOS patients aged 18～35 years from April 2021 to August 2022 in the Second Hospital of Shanxi Medical University who met the 2003 diagnostic criteria for Rotterdam as PCOS group,randomly selected 31 patients age-matched physical examination of healthy women and(or)due to male factors and(or)female infertility as NC group.All subjects were divided into IR group and NIR group according to the insulin resistance index(HOMA-IR),and PCOS patients were divided into PCOS with IR(PCOS+IR)and PCOS without IR(PCOS+NIR).The expression of vaspin,KLK7 was compared among different groups and analyzed the relationship with HOMA-IR.Results ①The levels of vaspin,KLK7,HOMA-IR and FINS in PCOS group were higher than in NC group,which were statistically significant(P<0.05).②Compared with the NIR group,the FBG,PBG,FINS,HOMA-IR,vaspin,and KLK7 levels were higher in the IR group,which were statistically significant differences(P<0.05).③ FBG,PBG,FINS,HOMA-IR,vaspin,and KLK7 in PCOS+IR group were significantly higher than in PCOS+NIR group,which were statistically significant differences(P<0.05).④ Vaspin was positively correlated with PBG,FINS,HOMA-IR,TG,LDL-C,and KLK7,and was negative correlation with HDL-C(P<0.05);KLK7 was positively correlated with LH,T,PBG,FINS,HOMA-IR,and vaspin(P<0.05).And showed a negative correlation with HDL-C(P<0.05).⑤ After correction of other variables,the results with a binary Logistic regression analysis prompted that KLK7 and LH were independent risk factors for PCOS(PKLK7=0.01,PLH=0.003).⑥ Through the ROC curve analysis,KLK7 and LH have certain value in the diagnosis of PCOS,and KLK7 combined with LH has a higher diagnostic value.Conclusion The serum of PCOS patients increased vaspin and KLK7 in different degrees,and vaspin and KLK7 were positively associated with HOMA-IR,suggesting that the high expression of vaspin and KLK7 is involved in the development of IR in PCOS;The elevated vaspin in PCOS serum was correlated with KLK7.KLK7 may also have value in predicting PCOS,and have higher predictive value combined with LH.
polycystic ovary syndromeinsulin resistancevaspinhuman kallikrein related petidase 7
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