A comparison of the effects of modified long-acting regimen and antagonist regimen on endometrial receptivity in patients with ovarian reserve dysfunction
Objective To investigate the effects of modified long-acting regimen and antagonist regimen on endometrial receptivity in patients with ovarian reserve dysfunction undergoing in vitro fertilization-embryo transfer(IVF-ET).Methods A total of 120 patients with reduced ovarian reserve function who received IVF-ET assisted pregnancy in Chengde Central Hospital from July 2018 to January 2023 were selected.Random number table method was used to divide the patients into modified long-acting long program group and antagonist group,60 cases in each group.In the antagonist group,gonadotropin-releasing hormone(GnRH)antagonist scheme was used,and in the modified long-acting long program group,GnRH agonist was used to improve long-acting long acting scheme.The dosage of gonadotropin(Gn),the days of Gn use,the levels of luteotropic hormone(LH),estradiol,progesterone and endometrial thickness on the day of hCG injection were compared between the two groups.The number of fresh embryo transplantation,implantation rate and clinical pregnancy rate of fresh embryo transplantation were recorded in the two groups.Results Compared with the antagonist group,the dosage of Gn was higher and the use days of Gn were longer in the modified long-acting long program group(P＜0.05).The LH level of the modified long-acting long program group on hCG injection day was lower than that of the antagonist group,and the estradiol,endometrial thickness and the number of fresh embryos transplanted were higher than those of the antagonist group,the differences were statistically significant(P＜0.05).The implantation rate and clinical pregnancy rate in the modified long-acting long program group were higher than those in the antagonist group,and there was no significant difference(P＞0.05).Conclusions GnRH antagonist scheme and GnRH agonist modified long-acting scheme have the same effect in IVF-ET assisted pregnancy patients with ovarian reserve dysfunction,GnRH antagonist scheme can reduce the use time and dosage of Gn,and GnRH agonist modified long-acting scheme has more advantages in improving patients'endometrium,so the scheme can be selected according to the actual situation.
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