Role of maternal serum catestatin in evaluation of preeclampsia and fetal cardiac function
Objective To analyze the relationship between maternal serum catestatin(CST)level and fetal cardiac function in patients with preeclampsia(PE).Methods From November 2021 to May 2022,49 pregnant women with PE in the third trimester(≥ 28 weeks of pregnancy)diagnosed in Lüshunkou Medical District,No.967 Hospital of Joint Logistics Support Force were recruited as the PE group,PE group was divided into 28～36 weeks group(26 cases)and ≥ 37 weeks group(23 cases)according to different gestational age,and 60 women with normal blood pressure in late pregnancy in the same period were included as the control group.Fetal heart function was evaluated by fetal echocardiography,and maternal serum CST level was detected by enzyme-linked immunosorbent assay.Results Compared with the control group,the pregnant women in the PE group had earlier gestational weeks of delivery,lower neonatal birth weight,1 min Apgar score,5 min Apgar score,higher serum urea nitrogen level,and lower fetal right ventricular sphericity index(RVSI),left ventricular myocardial performance index(LVMPI)and isovolumetric contraction time,the global longitudinal strain(LVGLS),global longitudinal strain of right ventricle(RVGLS),and ratio of early diastolic peak velocity(E)to late diastolic peak velocity(A)increased(P＜0.05).In addition,the serum CST level of pregnant women in the PE group was significantly lower than that in the control group[2.01(1.22,3.46)ng/mL vs.4.59(3.92,6.67)ng/mL,Z=-5.845,P＜0.001],serum CST levels of pregnant women ≥37 weeks in PE group were significantly higher than those at 28～36 weeks,with statistical significance(P＜0.05).The area under the curve of PE diagnosed by serum CST level was 0.826(95％CI:0.746-0.906)according to the analysis of the receiver operating characteristic curve.Multivariate Logistic analysis showed that high expression levels of serum CST was a protective factor for the occurrence of PE in pregnant women(OR:0.509;95％CI:0.327-0.792).In PE group,the serum CST level was positively correlated with LVMPI and isovolumic relaxation time,and negatively correlated with E/A ratio(P＜0.05).Conclusion The level of serum CST in pregnant women with PE in the third trimester is lower,and the low level of serum CST is related to the fetal cardiac dysfunction caused by PE,which can be used to assist in the evaluation of fetal cardiac function.
catestatinpreeclampsiapregnancyfetal cardiac function
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