Analysis of the potential role of chemoradiotherapy and immune maintenance therapy in patients with advanced cervical cancer
Objective To explore the efficacy of chemoradiotherapy combined with immune maintenance in the treatment of advanced cervical cancer and the reversal of malignant cervical squamous cell carcinoma(SiHa).Methods 110 cases of advanced cervical cancer patients in the Second Affiliated Hospital of Soochow University from April 2020 to August 2021 were selected,4 cases were dislodged during treatment,and 106 cases were finally counted,which were divided into two groups according to the randomized numerical table method,with 53 cases in each group.The control group was treated with concurrent chemoradiotherapy,and the observation group was treated with concurrent chemoradiotherapy combined with immune maintenance.Observed the clinical efficacy of the two groups,as well as tumor markers[carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125),osteopontin(OPN)],angiogenic factors[transforming growth factor-β1(TGF-β1),vascular endothelial cell growth factor(VEGF),basic fibroblast growth factor(bFGF)],biological behavior of cervical cancer SiHa cells before and after treatment,and the survival and incidence of toxic side effects were also compared between the two groups.Results The total effective rate of observation group was(64.15％)which was higher than that of control group(41.51％).After 2 and 6 weeks of treatment,the levels of serum CA125,CA199,OPN,TGF-β1,VEGF and bFGF,the expression of E6 and E7 protein,and miR-29、miR-101 in observation group were lower than those in control group,and the expression of p53 protein was higher than that in control group(P＜0.05).After 24 months of follow-up,the risk of disease progression and death in the observation group were lower than those in the control group(P＜0.05).During the treatment period,there was no statistically significant difference in the incidence of toxic side effects compared to the two groups(P＞0.05).Conclusion Concurrent chemoradiotherapy and immunomaintenance therapy can strengthen the anti-tumor effect,reduce the level of tumor markers,inhibit tumor angiogenesis,and have a positive effect on the malignant reversal of cervical cancer SiHa cells and improve the prognosis.
NETL
NSTL
万方数据
