Analysis of the preventive effect of deep hyperthermia combined with low-dose aspirin on adhesion after hysteroscopic surgery in patients with thin endometrium
Objective To analyze the effect of deep hyperthermia combined with low-dose aspirin on the prevention of intra uterine adhesion(IUA)in patients with thin endometrium after hysteroscopic surgery,and the effects on endometrial blood flow,tissue microvascular density(MVD)and vascular endothelial growth factor(VEGF)levels.Methods A total of 86 patients with thin endometrium who received hysteroscopic surgery in the Fifth People's Hospital of Qinghai Province from January 2019 to December 2021 were selected and divided into two groups according to the randomized control principle.The control group(43 cases)received oral low-dose aspirin therapy,and the study group(43 cases)received combined deep hyperthermia on the basis of the above,all of which were treated the next day after surgery and continued for 4 weeks.The clinical efficacy,IUA grade,endometrial thickness and blood flow parameters,MVD and VEGF were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group(P＜0.05).After treatment,mild,moderate and severe IUA grades in the study group were lower than those in the control group(P＜0.05).After treatment,the endometrial thickness of the study group was higher than that of the control group,the PI and RI were lower than that of the control group,and the number of endometrial vessels was higher than that of the control group and MVD and VEGF were higher than that of the control group,with statistical significance(P＜0.05).Conclusion Deep hyperthermia combined with low-dose aspirin can promote endometrial growth and enhance endometrial activity in patients with thin endometrium,which has significant curative effect.Moreover,this treatment regimen can improve the adhesion prevention effect of patients with hysteroscopic surgery,improve endometrial blood flow,and regulate the levels of MVD and VEGF.
deep hyperthermiaaspirinthin endometriumuterine adhesions
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