Relationship between menopausal age in women and the risk of postmenopausal use of antidepressants
Objective To explore whether early menopause in women is a risk factor for the use of antidepressants after menopause.Methods This study used NHANES data from 2015 to 2018,2 483 postmenopausal women were enrolled.Taking antidepressants as the dependent variable,converting the age of menopause to the categorical variable as the independent variable,and including other covariates,R statistical software package version 3.6.1 and Empower Stats software were used to calculate and conduct multiple factor Logistic regression analysis of correlation between age of menopause and antidepressant use.Results The proportion of women taking antidepressants was significantly higher among women ≤ 42 years of age.Divided postmenopausal women into three groups:natural menopause,hysterectomy,and hysterectomy combined with oophorectomy.In the natural menopausal group,it was found that the risk of taking antidepressants in the ≤ 42 years old group(OR=2.59,95％CI=1.60-4.19,P=0.001)was 2.59 times higher than that in the ≥ 50 years old group.In the group of hysterectomy combined with oophorectomy,the risk of taking antidepressants in the ≤ 42 years old group(OR=3.03,95％CI=1.46-6.30,P=0.003)was 3.03 times higher than that in the ≥50 years old group.Conclusion The risk of taking antidepressants after menopause was significantly increased in women aged ≤ 42 years who underwent natural menopause or underwent hysterectomy with oophorectomy.
age of menopauseantidepressantsdepressionpremature menopause
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