首页|环孢素A治疗不明原因反复种植失败患者的临床效果及安全性

环孢素A治疗不明原因反复种植失败患者的临床效果及安全性

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目的 探究环孢素A(cyclosporin A,CsA)治疗不明原因反复种植失败(repeated/recurrent implantation failure,RIF)患者的临床效果及安全性.方法 选择101例2021年3月至2022年12月在枣庄市妇幼保健院接受治疗的不明原因RIF患者作为研究对象,依据数字排列表法将其分为对照组(n=51,常规治疗)、观察组(n=50,常规治疗+CsA).对比两组患者活产率、临床妊娠率、胚胎着床率、流产率、免疫指标、妊娠并发症发生率、药物不良反应及新生儿情况.结果 观察组活产率、临床妊娠率及胚胎着床率较对照组更高,差异有统计学意义(P<0.05),而流产率与对照组相比降低,差异无统计学意义(P>0.05),流产率与对照组相比降低,差异无统计学意义(P>0.05);移植后观察组经CsA治疗后,肿瘤坏死因子-α(tumor necrosis factor,TNF-α)降低,而白介素-10(interleukin-10,IL-10)升高,与对照组相比差异有统计学意义(P<0.05);两组用药后妊娠并发症、胎儿孕期不良情况、产后1年内子代体格生长发育及DDST丹佛发育筛查比较,差异无统计学意义(P>0.05).结论 通过CsA治疗不明原因RIF患者,能提高患者的活产率、临床妊娠率、胚胎着床率,降低妊娠流产,而不增加患者妊娠并发症、胎儿孕期不良情况及子代异常发育的风险.
Clinical efficacy and safety of cyclosporine A in the treatment of patients with unexplained recurrent implantation failure
Objective To explore the clinical efficacy and safety of cyclosporin A(CsA)in the treatment of patients with unexplained repeated/recurrent implantation failure(RIF).Methods 101 patients with unexplained RIF who received treatment in Zaozhuang Maternal and Child Health Hospital from March 2021 to December 2022 were selected as the study objects,and were divided into control group(n=51,conventional treatment)and observation group(n=50,conventional treatment+CsA)according to the numerical ranking table method.The live birth rate,clinical pregnancy rate,embryo implantation rate,abortion rate,immune index,incidence of pregnancy complications,adverse drug reactions and neonatal conditions were compared between the two groups.Results The live birth rate,clinical pregnancy rate and embryo implantation rate of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).But there were no significant differences in the abortion rate between the two groups(P>0.05).After treatment with CsA,the value of tumor necrosis factor(TNF-α)decreased in the observation group after transplantation,while the value of interleukin-10(IL-10)increased.Compared with the control group,the difference was statistically significant(P<0.05).There were no significant differences in pregnancy complications,adverse fetal conditions,physical growth and development of offspring within 1 year after delivery and DDST Denver development screening between the two groups(P>0.05).Conclusion The treatment of patients with unexplained RIF with CsA can improve the live birth rate,clinical pregnancy rate,embryo implantation rate and reduce pregnancy abortion,but does not increase the risk of pregnancy complications,fetal adverse pregnancy and abnormal development of offspring.

repeated implantation failurecyclosporin Aoffspring riskembryo implantation rate

李会、褚青青、仇雪梅、赵淑芹、王静、王磊、王可可、边晓露

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277000 山东枣庄,枣庄市妇幼保健院生殖与遗传医学中心

反复移植着床失败 环孢素A 子代风险 胚胎着床率

山东省医药卫生科技发展计划

202005030722

2024

中国计划生育和妇产科
中国医师协会 四川省医学情报研究所

中国计划生育和妇产科

CSTPCD
影响因子:1.116
ISSN:1674-4020
年,卷(期):2024.16(8)