高强度聚焦超声联合地诺孕素对子宫腺肌病的治疗效果评估
Evaluation of the therapeutic effect of high intensity focused ultrasound combined with dinogest on adenomyosis
史丽坤 1赵明阳 1宋学薇 2贾凡 3卢杰红 1杨秀梅1
作者信息
- 1. 061000 河北 沧州,沧州市人民医院本部妇科
- 2. 061000 河北 沧州,沧州市人民医院海扶室
- 3. 061000 河北 沧州,沧州市人民医院产科
- 折叠
摘要
目的 探讨高强度聚焦超声联合地诺孕素对子宫腺肌病患者的治疗效果.方法 选取2017年10月至2021年2月在沧州市人民医院妇科接受治疗的120例子宫腺肌病患者,按照治疗方法分组.对照组患者予以地诺孕素口服治疗,研究组患者在对照组的基础上予以高强度聚焦超声治疗,比较两组患者的治疗效果以及治疗前后卵巢功能、痛经改善情况、子宫体积及血管相关指标的变化.结果 研究组治疗有效率(88.33％)高于对照组(68.33％)(P＜0.05);治疗后,两组患者LH、E2、FSH水平均较治疗前降低,差异有统计学意义(P＜0.05),但组间比较差异无统计学意义(P＞0.05);两组患者治疗后的痛经评分、月经量评分、子宫体积、血管内皮生长因子(vascular endothelial growth factor,VEGF)、血管生成素-2(angiopoietin-2,Ang-2)较治疗前均降低,且研究组低于对照组,差异有统计学意义(P＜0.05).结论 高强度聚焦超声联合地诺孕素治疗子宫腺肌病患者能够协同增效,改善临床症状及相关因子水平,且不影响卵巢功能.
Abstract
Objective To investigate the therapeutic effect of high-intensity focused ultrasound(HIFU)combined with dienogest in patients with adenomyosis.Methods A total of 120 patients with adenomyosis who received treatment in the Department of Gynecology of Cangzhou People's Hospital from October 2017 to February 2021 were selected and grouped according to the treatment method.The patients in the control group were treated with oral dienogest,and the patients in the study group were treated with HIFU on the basis of the control group,and the treatment effect of the two groups was compared,as well as the changes of ovarian function,dysmenorrhea,uterine volume and vascular related indexes before and after treatment.Results The effective rate of treatment in the study group(88.33％)was higher than that in the control group(68.33％)(P＜0.05).After treatment,the levels of LH,E2 and FSH in the two groups were significantly lower than those before treatment(P＜0.05),but there was no significant difference between the two groups(P＞0.05).The dysmenorrhea score,menstrual flow score,uterine volume,vascular endothelial growth factor(VEGF)and angiopoietin-2(Ang-2)level were significantly lower in the two groups than before treatment,and the study group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion HIFU combined with dienogest in treating adenomyosis patients can synergistically improve clinical symptoms and related factors,without affecting ovarian function.
关键词
高强度聚焦超声/地诺孕素/子宫腺肌病/卵巢功能/月经量/血管生成素-2Key words
high intensity focused ultrasound/dienogest/adenomyosis/ovarian function/menstrual volume/angiopoietin-2引用本文复制引用
基金项目
河北省卫生健康委办公室医学科学研究课题(2023)(20232088)
出版年
2024
NETL
NSTL
万方数据