Expression levels and clinical significance of serum insulin and 25-hydroxyvitamin D3 in type Ⅰ endometrial carcinoma
Objective To investigate the expression levels and clinical significance of peripheral blood serum insulin and 25(OH)D3 in type Ⅰ endometrial carcinoma(EC).Methods 30 patients with type Ⅰ EC(observation group)admitted to Lianyungang Hospital Affiliated to Xuzhou Medical University from July 2021 to July 2022 and 30 healthy women(control group)in the same period were selected as the study objects.The levels of fasting insulin(FINS)and 25(OH)D3 were detected by chemiluminescence method,and the insulin resistance index(HOMA-IR)was calculated.Results In both diabetic and non-diabetic patients,the serum insulin and HOMA-IR in observation group were significantly higher than those in control group,while the serum 25(OH)D3 was lower than those in the control group,with a statistically significant difference(P＜0.05).There was no statistically significant difference in FINS levels and HOMA-IR between patients with type Ⅰ EC at different FIGO stages,histological grading,depth of muscle infiltration,presence or absence of lymph node metastasis,expression of estrogen and progesterone receptors(P＞0.05).As the FIGO stage increased,histological grading increased,and the depth of muscle infiltration increased,the serum 25(OH)D3 levels in patients showed a downward trend,with statistical significance(P＜0.05).There was no significant correlation with lymph node metastasis,expression of estrogen and progesterone receptors,and the difference was not statistically significant(P＞0.05).Conclusion Patients with type Ⅰ EC have significantly elevated serum insulin levels and significantly decreased serum 25(OH)D3 levels.They may induce the type Ⅰ EC and have certain clinical guidance significance for the diagnosis and progression of EC.
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