Construction and analysis of early prediction model of endometrial receptivity in IVF-ET patients based on multimodal ultrasound
Objective To construct and validate an early prediction model for endometrial receptivity in in vitro fertilization-embryo transfer(IVF-ET)patients based on multimodal ultrasound.Methods A total of 300 infertility patients from May 2020 to May 2022 in the Department of Reproductive Medicine of Cangzhou Hospital of Integrated Chinese and Western Medicine were selected and divided into pregnancy group and control group according to the pregnancy outcome.All patients underwent endometrial receptivity tests with multimodal ultrasound and were treated with IVF-ET.The general information and uterine receptivity were compared between the two groups.Multivariate Logistic regression was used to analyze the relationship between relevant indicators and pregnancy outcomes in IVF-ET patients.R software was used to establish a nomogram prediction model for pregnancy outcomes in IVF-ET patients by various influencing factors and verify it.Results Of the patients included in the study,96 had successful clinical pregnancy and were classified as the pregnancy group,and the remaining 188 were the control group,the pregnancy success rate was 33.80％.There was no significant difference in clinical data such as infertility time,basic FSH and endometrial blood flow score between the two groups(P＞0.05).The endometrial thickness and uterine volume of the pregnancy group were higher than those of the control group,the proportion of endometrial morphology of type A and type B,the proportion of endometrial blood flow of type Ⅲ were higher than those of the control group,and the number of peristalsis and RI were lower than those of the control group,and the difference was statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that endometrial morphology(OR=0.455),peristalsis times(OR=0.104)and RI(OR=0.001)were independent risk factors for clinical pregnancy success in IVF-ET patients;endometrial thickness(OR=2.164),uterine volume(OR=8.659)and endometrial blood flow(OR=1.806)were protective factors for clinical pregnancy success in IVF-ET patients.When the factors related to clinical pregnancy success in IVF-ET patients were included in the nomogram,the C-index of the factors related to clinical pregnancy success in IVF-ET patients was 0.963.Conclusion The nomogram constructed from the endometrial thickness,endometrial morphology and other endometrial receptivity factors under multimodal ultrasound examination can be used to predict the clinical pregnancy outcomes of IVF-ET patients,which is helpful to adjust the treatment plan early and improve the pregnancy success rate.
万方数据
维普
