Study on the correlation between ILC2 and the Th17/Treg ratio in patients with recurrent spontaneous abortion
Objective To explore the role of type 2 inherent lymphocytes(ILC2)in recurrent abortion and its correlation with the Th17/Treg ratio.Methods Selected 30 patients with recurrent abortion in the Outpatient Department of the Gynecology Center of the First Affiliated Hospital of Xinjiang Medical University from October 2022 to October 2023 as the recurrent abortion group,and another 30 normal pregnant women as the normal pregnancy group,30 women with normal gestational age and no pregnancy during the same period as the pregnancy-preparing group.Flow cytometry was used to detect the proportion of ILC2 in CD45+cells,Th17 and Treg cells accounted for CD4+T lymphocytes in the peripheral blood of each group,and the correlation of ILC2 and the ratio of Th17/Treg in patients with recurrent abortion by Pearson method.Results Compared with the pregnancy-preparing group(0.634％±0.064％)and the normal pregnancy group(0.570％±0.028％),the proportion of ILC2 in peripheral blood in the recurrent abortion group(1.457％±0.887％)was significantly increased,and the difference was statistically significant(P＜0.01).Comparing the normal pregnancy group and the pregnancy-preparing group,the difference was not statistically significant(P＞0.05).Compared with the normal pregnancy group and the pregnancy-preparing group,the proportion of Th17 cells in CD4+T cells in the recurrent abortion group had increased significantly,the proportion of Treg cells decreased significantly,and the difference was statistically significant(P＜0.05),while the difference of the proportion of Th17 cells and Treg cells between the normal pregnancy group and the pregnancy-preparing group had no statistical significance.The correlation analysis showed that ILC2 was positively correlated with the Th17/Treg ratio in the recurrent abortion group(r=0.798,P＜0.001).Conclusion The proportion of ILC2 cells and Th17 cells in the peripheral blood of patients with recurrent abortion increases,the proportion of Treg cells decreases,and the ratio of ILC2 to Th17/Treg is positively correlated.It suggests that ILC2 participates in the development of recurrent abortion,affecting normal pregnancy,and recurrent abortion may be related to Th17/Treg imbalance.
recurrent spontaneous abortionILC2normal pregnancywomen preparing for pregnancyTh17/Treg ratio
万方数据
维普
