目的 探讨不同卵泡输出率(follicular output rate,FORT)的高龄患者体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)结局.方法 回顾性分析2017年12月至2022年12月在四川省妇幼保健院生殖医学中心行IVF-ET助孕治疗的603例高龄患者,女方年龄≥35岁,按照FORT值分为3组:低FORT 组,FORT 位于 33％以下者(FORT＜50.00％,n=201);中 FORT 组,FORT 位于 33％～67％(FORT 处于50.00％～83.00％,n=201);高 FORT 组,FORT 位于 67％以上者(FORT＞83.00％,n=201).比较3 组患者一般情况、超排卵指标、卵母细胞及胚胎质量、胚胎移植结局.结果 3组扳机日雌二醇(estrogen,E2)水平、孕酮(progesterone,P)水平、获卵数、成熟卵(mature oocytes,MII)数、正常受精卵数、day 3(D3)卵裂胚数高FORT组最高,其次为中FORT组,低FORT组最低差异有统计学意义(P＜0.05).高FORT组优质囊胚率明显高于低FORT组(P＜0.05).临床妊娠率、持续妊娠率、活产率高FORT组最高,其次为中FORT组,低FORT组最低,但差异无统计学意义(P＞0.05).结论 高龄患者IVF-ET中卵巢高反应有利于卵母细胞及提高胚胎质量,可能有利于IVF-ET结局.
The influence of follicular output rate on outcomes of in vitro fertilization and embryo transfer in aged women
Objective To explore the outcomes of in vitro fertilization and embryo transfer(IVF-ET)in aged women with different follicle output rate(FORT).Methods Retrospective analysis of 603 aged patients of IVF-ET assisted pregnancy treatment in the Reproductive Medicine Center of Sichuan Provincial Maternal and Child Health Hospital from December 2017 to December 2022.The female age ≥35 years old,all patients were divided into three groups according to the their FORT value:low FORT group,33％quantile(FORT value＜50.00％,n=201);medium FORT group,33％～67％quantile,(FORT value equaled to 50.00％～83.00％,n=201);high FORT group,≥ 67％quantile,(FORT value＞83.00％,n=201).The general condition,superovulation index,oocyte and embryo quality,embryo transfer outcome were compared.Results There were statistically significant differences in the levels of estradiol(E2),progesterone(P)on the trigger day,the number of oocytes,mature oocytes,normal fertilized oocytes and day 3(D3)cleavage embryos in three groups,highest in the high FORT group,followed by the medium FORT group and the low FORT group(P＜0.05).The rate of high-quality blastocysts in the high FORT group was significantly higher than that in the low FORT group(P＜0.05).The clinical pregnancy rate,sustained pregnancy rate,and live birth rate were highest in the high FORT group,followed by the medium FORT group and the low FORT group,but the difference was not statistically significant(P＞0.05).Conclusion High ovarian response in aged women with IVF-ET is beneficial for oocyte and improving embryo quality,which may be beneficial for IVF-ET outcomes.
万方数据
维普
