首页|血清AMH对不同年龄段PCOS患者的诊断和预后价值

血清AMH对不同年龄段PCOS患者的诊断和预后价值

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目的 分析血清抗苗勒管激素(anti-Müllerian hormone,AMH)水平对于各年龄段多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者的诊断和预后价值.方法 选取2022年6月至2023年2月于成都市锦江区妇幼保健院就诊的年龄20~40岁的157例PCOS患者为观察组,同期来院体检的135例同年龄段、月经规律的孕前检查者为对照组.再根据年龄,将观察组和对照组分为两个亚组:20~<30岁组和30~40岁组,比较各组年龄和AMH水平,使用GraphPad Prism进行受试者工作特征(ROC)曲线分析,评估AMH在不同年龄组PCOS诊断中的效能.观察组干预半年后,对所有患者进行跟踪随访,排除资料不完整者并根据超声诊断分为预后良好组(36例)、预后不良组(11例),比较两组的一般情况及AMH水平,分析AMH对PCOS的预后价值.结果 观察组AMH水平高于对照组,差异有统计学意义(P<0.05).观察组不同年龄亚组的AMH水平均高于对照组,对照组中20~<30岁组AMH水平高于30~40岁组,差异均有统计学意义(P<0.05).观察组内不同年龄亚组AMH水平比较,差异无统计学意义(P>0.05).AMH诊断20~<30岁组、30~40岁组PCOS 的 ROC 曲线 AUC 分别为 0.8575、0.9257,最佳截断值分别为 6.22 ng/mL、4.57 ng/mL.Spearman 相关分析结果显示AMH与PCOS的预后无显著相关性(P>0.05).结论 PCOS患者AMH水平高于普通人群,AMH在诊断PCOS中具有较高灵敏度和特异度,且不同年龄段其诊断效能不同,最佳截断值也不同,但AMH在PCOS预后评估中意义不明显.
Diagnostic and prognostic value of serum AMH in PCOS patients of different ages
Objective To analyze the diagnostic and prognostic value of serum anti-Müllerian hormone(AMH)level in patients with polycystic ovary syndrome(PCOS)at different ages.Methods From June 2022 to February 2023,157 PCOS patients aged 20~40 years old who were treated in Jinjiang Maternal and Child Health Hospital of Chengdu were selected as the observation group,and 135 pre-pregnancy patients of the same age and with regular menstruation who came to the hospital for physical examination during the same period were selected as the control group.According to the age,the observation group and the control group were divided into two subgroups:20~<30-years-old group and 30~40-years-old group,and the age and AMH level of each group were compared.Receiver operating characteris(ROC)curve analysis was performed using GraphPad Prism to evaluate the efficacy of AMH in the diagnosis of PCOS in different age groups.After half a year of intervention in the observation group,all patients were followed up,and those with incomplete data were excluded and then divided into good prognosis group(36 cases)and poor prognosis group(11 cases)according to ultrasound diagnosis,and the general condition and AMH level of the two groups were compared,and the prognostic value of AMH on PCOS was analyzed.Results The AMH level in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The AMH levels of different age subgroups in the observation group were higher than those in the control group,and the AMH levels in the 20~<30-year-old group in the control group were higher than those in the 30~40-year-old group,and the differences were statistically significant(P<0.05).There was no significant difference in AMH levels among different age subgroups in the observation group(P>0.05).The AUC of ROC curves for AMH diagnosis of PCOS in the 20~<30-year-old group and 30~40-year-old group were 0.8575 and 0.9257,respectively,and the optimal cut-off values were 6.22 ng/mL and 4.57 ng/mL,respectively.Spearman correlation analysis showed that there was no significant correlation between AMH and prognosis of PCOS(P>0.05).Conclusion The level of AMH in PCOS patients is higher than that in the general population,and AMH has high sensitivity and specificity in the diagnosis of PCOS,and its diagnostic efficacy is different in different ages,with different optimal cut-off values,but AMH has no obvious significance in the prognostic assessment of PCOS.

agepolycystic ovary syndromeanti-müllerian hormone

刘咏梅、向兵、李超

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610040 四川 成都,成都市锦江区妇幼保健院检验科

年龄 多囊卵巢综合征 抗苗勒管激素

成都市卫生健康委员会2023年成都市医学科研课题

2023086

2024

中国计划生育和妇产科
中国医师协会 四川省医学情报研究所

中国计划生育和妇产科

CSTPCD
影响因子:1.116
ISSN:1674-4020
年,卷(期):2024.16(9)