首页|温阳活血化息汤联合地屈孕酮片预防子宫内膜息肉术后复发的疗效

温阳活血化息汤联合地屈孕酮片预防子宫内膜息肉术后复发的疗效

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目的 观察温阳活血化息汤联合地屈孕酮片预防子宫内膜息肉患者术后复发的疗效.方法 选择2019年2月至2021年10月河北省退役军人总医院妇产科的108例行宫腔镜电切术的子宫内膜息肉患者为研究对象,随机数字表法分为对照组和观察组,每组各54例.对照组术后口服地屈孕酮片治疗,观察组口服地屈孕酮片的同时给予温阳活血化息汤治疗.评估两组中医证候评分、子宫内膜厚度、性激素指标水平、炎性因子水平以及术后复发率.结果 治疗3个月后,观察组中医证候总分低于对照组(P<0.05);两组患者治疗后、治疗后3个月以及治疗后9个月的子宫内膜厚度明显低于治疗前,且观察组三个时间段的子宫内膜厚度明显低于对照组相应时间厚度(P<0.05);两组治疗后和治疗后3个月的雌二醇(estradiol,E2)水平均降低,且观察组低于对照组,孕酮(progesterone,P)水平均升高,且观察组高于对照组(P<0.05);两组患者治疗后和治疗后3个月的血清白细胞介素6和肿瘤坏死因子-α水平降低,且观察组低于对照组(P<0.05);观察组患者术后12个月的疾病复发率(1.85%)显著低于对照组(12.96%),差异均有统计学意义(P<0.05).结论 温阳活血化息汤联合地屈孕酮片可能通过调节性激素水平和炎性因子水平来提高临床疗效,降低术后复发率.
Effect of Wen Yang Huo Xue Hua Xi Tang combined with dydrogesterone tablets in preventing postoperative recurrence of endometrial polyps
Objective To observe the effect of Wen Yang Huo Xue Hua Xi Tang combined with dydrogesterone tablet on preventing recurrence of endometrial polyps patients after operation.Methods 108 patients with endometrial polyps who underwent hysteroscopic resection at the Department of Obstetrics and Gynecology in Hebei Provincial Veterans General Hospital from February 2019 to October 2021 were selected as the study subjects.They were randomly divided into the control group and the observation group using a random number table method,with 54 cases in each group.The control group received postoperative oral treatment with dydrogesterone tablet,while the observation group received treatment with Wen Yang Huo Xue Hua Xi Tang while taking dydrogesterone tablets orally.Evaluated two groups of traditional Chinese medicine syndrome scores,endometrial thickness,levels of sex hormone indicators,levels of inflammatory factors,and postoperative recurrence rate.Results After 3 months of treatment,the total score of traditional Chinese medicine syndromes in the observation group was lower than that in the control group(P<0.05);the endometrial thickness of the two groups of patients after treatment,3 months after treatment,and 9 months after treatment was significantly lower than before treatment,and the endometrial thickness of the observation group was significantly lower than the corresponding time thickness of the control group in the three time periods(P<0.05);the levels of estradiol(E2)decreased in both groups after treatment and 3 months after treatment,and the observation group was significantly lower than the control group,while the levels of progesterone(P)increased in both groups,and the observation group was higher than the control group(P<0.05);serum levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)decreased in two groups of patients after treatment and 3 months after treatment,and the observation group was lower than the control group(P<0.05);the disease recurrence rate of the observation group patients at 12 months after surgery(1.85%)was significantly lower than that of the control group(12.96%),and the difference was statistically significant(P<0.05).Conclusion The combination of Wen Yang Huo Xue Hua Xi Tang and dydrogesterone tablets may improve clinical efficacy and reduce postoperative recurrence rate by regulating the levels of sex hormones and inflammatory factors.

endometrial polypshysteroscopic resectiondydrogesterone tabletsWen Yang Huo Xue Hua Xi Tang

王瑞萍、曾立叶、李楠、赵运清、毛秀菊、肖茂翠

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054000 河北 邢台,河北省退役军人总医院妇产科

054000 河北 邢台,河北省退役军人总医院综合内科

054000 河北 邢台,河北省退役军人总医院功能科

054000 河北 邢台,河北省退役军人总医院康复二科

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子宫内膜息肉 宫腔镜电切术 地屈孕酮片 温阳活血化息汤

邢台市重点研发计划项目

2022ZC163

2024

中国计划生育和妇产科
中国医师协会 四川省医学情报研究所

中国计划生育和妇产科

CSTPCD
影响因子:1.116
ISSN:1674-4020
年,卷(期):2024.16(10)