Clinical effect of Qufeng Huoxue Zhitong Recipe combined with ibuprofen tablets on patients with primary dysmenorrhea
Objective To observe the therapeutic effect of Qufeng Huoxue Zhitong Recipe combined with ibuprofen on primary dysmenorrhea patients.Methods 84 cases diagnosed with primary dysmenorrhea in First Affiliated Hospital of Xinjiang Medical University from January 2022 to January 2023 were randomly divided into a control group and an experimental group,with 42 cases in each group.The control group was given ibuprofen orally,and the experimental group was given ibuprofen+Qufeng Huoxue Zhitong Recipe orally.Evaluated the clinical efficacy of patients of two groups after 3 months of treatment.The overall improvement of symptoms,pain,and quality of life in both groups after treatment were evaluated by observing the changes in traditional Chinese medicine syndrome scores,CMSS dysmenorrhea symptom scale scores,VAS pain score,and SF-36 quality of life score.Serum prostaglandin F2α(PGF2α),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor α(TNF-α)were detected by ELISA before and after treatment.Results There was no statistically significant difference in all indicators between the two groups of patients before treatment(P＞0.05).After 3 months of treatment,the clinical efficacy of the experimental group was significantly better than that of the control group(P＜0.05).Compared with before treatment,the traditional Chinese medicine syndrome score,CMSS score,and VAS score of both groups were significantly reduced,while the SF-36 score was significantly improved(P＜0.05).Serum levels of PGF2α and hs-CRP,IL-6,TNF-α decreased significantly(P＜0.05).After treatment,the traditional Chinese medicine syndrome score,CMSS score,VAS score and serum PGF2α,hs-CRP,IL-6,TNF-α levels in the experimental group were significantly lower than those in the control group,SF-36 score was significantly higher than that in the control group(P＜0.05).Conclusion Qufeng Huoxue Zhitong Recipe has a good therapeutic effect on primary dysmenorrhea,which can alleviate the degree of dysmenorrhea,improve related symptoms,and improve the efficacy of ibuprofen,its mechanism may be related to reducing the secretion of serum inflammatory factors and regulating the level of prostate metabolites.
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