首页|补益心脾法联合双歧杆菌三联活菌对心脾两虚产后抑郁患者肠道菌群的影响

补益心脾法联合双歧杆菌三联活菌对心脾两虚产后抑郁患者肠道菌群的影响

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目的 分析补益心脾法联合双歧杆菌三联活菌对心脾两虚产后抑郁患者肠道菌群的影响.方法 选取中国人民解放军联勤保障部队第九○八医院2020年7月至2022年7月收治的95例心脾两虚产后抑郁患者为研究对象,按照随机数字表法分为A、B、C 3组.A组采用参芪解郁方颗粒治疗,B组采用双歧杆菌三联活菌治疗,C组采用两者联合治疗,检测各组肠道菌群、抑郁程度、神经递质、性激素水平.结果 与治疗前相比,治疗后各组双歧杆菌、乳酸杆菌、5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)、γ-氨基丁酸(GABA)、雌二醇(E2)水平升高,大肠埃希菌、肠球菌、孕酮(P)水平、爱丁堡产后抑郁量表评分(EPDS)、抑郁自评量表(SDS)评分降低(P＜0.05).与A组、B组相比,C组治疗后双歧杆菌、乳酸杆菌、5-HT、NE、DA、GABA、E2水平较高,大肠埃希菌、肠球菌、P水平、EPDS、SDS评分较低(P＜0.05).结论 补益心脾法联合双歧杆菌三联活菌治疗,可使心脾两虚产后抑郁患者肠道菌群、性激素得到改善,降低患者抑郁评分,提高患者神经递质水平,临床使用效果较好.
Effect of supplementing heart spleen method combined with Bifidobacterium triplet live bacteria on intestinal flora in postpartum depression patients with two deficiency of heart spleen
Objective To analyze the effects of supplementing heart spleen method combined with Bifidobacterium triple live bacteria on intestinal flora in postpartum depression patients with heart spleen two deficiency.Methods 95 postpartum depression patients with heart and spleen deficiency admitted to the 908th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China from July 2020 to July 2022 were selected as the research subjects.Divided into groups A,B,and C according to the random number table method,group A were treated with Shenqi Jieyu formula granules,group B was treated with Bifidobacterium triple live bacteria,and group C was treated with Shenqi Jieyu formula granules combined with Bifidobacterium triple live bacteria.The gut microbiota,degree of depression,neurotransmitters,and sex hormone levels of patients in each group were detected.Results Compared with before treatment,the levels of bifidobacteria,Lactobacillus,serotonin(5-HT),noradrenaline(NE),dopamine(DA),γ-aminobutyric acid(GABA),estradiol(E2)in each group of patients increased after treatment,Escherichia coli,Enterococcus,progesterone(P),Edinburgh Postpartum Depression Scale(EPDS),and Depression Self-rating Scale(SDS)decreased(P＜0.05).Compared with group A and group B,the patients in the group C had higher levels of Bifidobacterium,Lactobacillus,5-HT,NE,DA,GABA,E2,and lower levels of Escherichia coli,Enterococcus,P,EPDS,and SDS scores after treatment(P＜0.05).Conclusion The treatment of postpartum depression patients with deficiency of heart and spleen by supplementing heart and spleen method combined with Bifidobacterium triple live bacteria can lead to the improvement of intestinal flora and sex hormones,reduce the depression score of patients,improve the levels of neurotransmitters,and have better effects in clinical use.

postpartum depressiondeficiency of the heart and spleensupplementing heart spleen methodBifidobacterium triplet living bacteriagut flora

徐芳、陈文玲、潘凌云、王颖、侯思嘉、翁金华、黄杰

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330001 江西 南昌,中国人民解放军联勤保障部队第九○八医院妇产科

产后抑郁 心脾两虚 补益心脾法 双歧杆菌三联活菌 肠道菌群

江西省中医药管理局科技计划课题

2022B089

2024

10.3969/j.issn.1674-4020.2024.10.16

中国计划生育和妇产科
中国医师协会 四川省医学情报研究所

中国计划生育和妇产科

CSTPCD
影响因子：1.116
ISSN：1674-4020
年,卷(期)：2024.16(10)