The effect of liquid heating during laparoscopic radical cervical cancer surgery under general anesthesia on patients'stress state and cognitive function
Objective To study the effect of liquid heating during laparoscopic radical cervical cancer surgery under general anesthesia on patients'stress state and cognitive function.Method 120 patients who underwent elective cervical cancer radical surgery at China Aerospace Science and Industry Group 731 Hospital from January 2021 to December 2022 were selected and randomly divided into a control group and a study group,with 60 patients in each group,using a random number table method.The control group received routine intervention during surgery,while the study group used liquid heating to control body temperature during surgery.The temperature changes at various time points during surgery(1 hour,2 hours,3 hours,and at the end of surgery),postoperative recovery quality(extubation time,complete wakefulness time),stress indicators[malondialdehyde(MDA),glutathione peroxidase(GSH Px),superoxide dismutase(SOD)]levels,cognitive function[Mini Mental State Examination(MMSE)score],and cellular immune indicators(CD3+,CD4+)were compared between the two groups.Results There were 15 cases,26 cases,32 cases,and 38 cases of hypothermia at 1 hour,2 hours,3 hours during surgery,and at the end of surgery in the control group,respectively.There were 6 cases,10 cases,12 cases,and 16 cases in the study group,respectively.The incidence of hypothermia in the study group was lower than that in the control group(P＜0.05).The postoperative extubation time[(18.14±1.64)minutes]and complete awakening time[(43.05±4.08)minutes]in the study group were shorter than those in the control group[(21.56±2.79)minutes,(58.43±6.11)minutes](P＜0.05).Before surgery,there was no statistically significant difference in serum SOD,MDA,GSH-Px,CD3+,CD4+,and MMSE scores between the two groups(P＞0.05).Compared with before surgery,serum MDA significantly increased(P＜0.05)and GSH-Px,SOD,CD3+,and CD4+significantly decreased(P＜0.05)in both groups at 24 hours after surgery.However,the control group had a greater increase in serum MDA at 24 hours after surgery and a greater decrease in GSH-Px,SOD,CD3+,and CD4+(P＜0.05).Compared with before surgery,the MMSE scores of both groups decreased significantly at 24 and 72 hours after surgery,but the MMSE scores of the study group at 24 and 72 hours after surgery were significantly higher than those of the control group(P＜0.05).Conclusion Intraoperative liquid heating technology can effectively reduce intraoperative and postoperative hypothermia in patients undergoing laparoscopic radical cervical cancer surgery under general anesthesia,promote postoperative recovery,reduce stress response,and improve cognitive function and immune functions,it is a practical and effective intervention measure.
cervical cancerlaparoscopic radical surgery under general anesthesialiquid heatingstress statecognitive function
万方数据
维普
