Clinical effect of simvastatin combind with N-acetylcysteine in the treatment of patients with bronchial asthma
Objective To investigate the clinical effect of simvastatin combined with N-acetylcysteine in the treatment of patients with bronchial asthma.Methods A total of 61 patients with bronchial asthma were selected as research subjects and randomly divided into the control group(n=31)or the observation group(n=30).The control group was treated conventionally,based on which the observation group was treated with a combination of simvastatin and N-acetylcysteine additionally,and both groups were treated for 6 weeks.The clinical efficacy,lung function and inflammatory factors levels before and after treatment,and the incidence of adverse reactions during treatment were compared between the two groups.Results After 6 weeks of treatment,the total effective rate of treatment of the observation group was higher than that of the control group;the tested peak expiratory flow over expected,forced vital capacity,and forced expiratory volume in 1 second were increased in both groups,and the above indexes in the observation group were higher than those in the control group;the serum levels of interleukin-6,interleukin-17,and tumor necrosis factor-α in the two groups were decreased,and the above indexes in the observation group were lower than those in the control group(all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions during treatment between the two groups(P＞0.05).Conclusion Simvastatin combined with N-acetylcysteine has a good clinical effect in the treatment of patients with bronchial asthma,which can effectively improve their lung function,reduce inflammatory factors levels,alleviate airway inflammation,and the adverse reactions are mild.
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