Correlations of vitamin A and vitamin E levels with wheezing disease in children
Objective To investigate the correlations of vitamin A and vitamin E levels with wheezing disease in children.Methods A total of 234 children with wheezing disease were selected as the wheezing group,while 244 children undergoing healthy physical examinations were selected as the control group.The vitamin A and vitamin E levels were compared between the two groups,and their correlations with lung function in the wheezing group were analyzed with Pearson or Spearman correlation.Results The vitamin A level and the proportion of children with normal vitamin A levels in the wheezing group were lower than those in the control group,and the proportions of children with subclinical vitamin A deficiencies and children with suspected subclinical vitamin A deficiencies were higher than those in the control group(all P＜0.05).The vitamin E level and the proportion of children with normal vitamin E levels in the wheezing group were lower than those in the control group,and the proportions of children with vitamin E defiiciencies and children with vitamin E insufficiencies were higher than those in the control group(all P＜0.05).The results of Pearson correlation analysis showed that there was no correlation between the vitamin A level and ratio of time to peak tidal expiratory flow to total expiratory time,volume at peak tidal expiratory flow,fractional exhaled nitric oxide(FeNO),immunoglobulin(Ig)E,IgG,or the absolute value of peripheral blood eosinophils(EOS)(all P＞0.05).There was no correlation between the vitamin E level and ratio of time to peak tidal expiratory flow to total expiratory time,volume at peak tidal expiratory flow,IgE,IgG,or the absolute value of peripheral blood EOS(all P＞0.05),but there was negative correlation between the vitamin E level and FeNO(P＜0.05).Conclusion Vitamin A and vitamin E levels in children with wheezing disease are relatively low,and their vitamin E levels are negatively correlated with FeNO.
万方数据
维普
