18F-FDG PET and 9-item subjective cognitive decline questionnaire for diagnosing subjective cognitive decline
Objective To observe the value of 18F-FDG PET and 9-item subjective cognitive decline questionnaire(SCD-Q9)for diagnosing subjective cognitive decline(SCD).Methods Data of 18F-FDG PET images as well as evaluation results of SCD-Q9 of 50 SCD patients(SCD group)and 49 healthy subjects(control group)were retrospectively analyzed.Taken the pons as reference,whole-brain voxel quantification was performed to calculate the standard uptake value ratio(SUVR).The abnormal glucose metabolism pattern of SCD was observed,and the diagnostic efficacy of SUVR reduction brain regions combining with SCD-Q9 for SCD was analyzed.Results Compared with control group,SUVR of left medial superior frontal gyrus and right superior frontal gyrus significantly decreased,while of left calcarine increased in SCD group(GRF corrected,all P＜0.01 for voxel level,all P＜0.05 for cluster level).The sensitivity,specificity and area under the curve(AUC)of left medial superior frontal gyrus and right superior frontal gyrus for diagnosing SCD was 54.00％,77.60％and 0.660,respectively,while combining with SCD-Q9 was 86.00％,75.50％and 0.840,respectively,with significantly different AUC(P＜0.05).Conclusion 18 F-FDG PET brain metabolism imaging could display abnormal metabolic patterns of SCD,which combining with SCD-Q9 was helpful for diagnosing SCD.
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