Diffusion kurtosis imaging for evaluation on topological damages of gray matter structural network in patients with Parkinson disease
Objective To observe the value of structural network of gray matter constructed based on diffusion kurtosis imaging(DKI)for evaluation on topological damages in patients with Parkinson disease(PD).Methods Totally 76 patients with PD(PD group)and 80 normal controls(NC group)were prospectively enrolled.The structural networks of gray matter were constructed based on DKI data of brain.The topological properties(global,nodal and modular)of structural network were compared between groups.Results In terms of global properties,the values of small world properties(γ,λ,σ)and characteristic path length in PD group were significantly higher,while local efficiency was significantly lower than those in NC group(all P＜0.05).In terms of nodal properties,PD group showed significantly decreased degree centrality and nodal efficiency of several nodes compared with those in NC group(Bonferroni correction,all P＜0.000 6),mainly distributed in the basal ganglia,frontal lobe,parietal lobe and occipital lobe.In terms of modular connectivity,compared with NC group,extensive inter-modular connections as well as intra-modular connections within sensorimotor network,default mode network,fronto-parietal network and visual network significantly reduced in PD group(Bonferroni correction,all P＜0.01).Conclusion Structural network of gray matter derived from DKI could reflect topological alterations of network in patients with PD.
万方数据
维普
