Conventional MRI and diffusion weighted imaging for differential diagnosis of benign and malignant peripheral nerve sheath tumors
Objective To differentiate benign and malignant peripheral nerve sheath tumors(PNST)with conventional MRI and diffusion weighted imaging(DWI).Methods MRI data of 119 patients with PNST confirmed by pathology were retrospectively analyzed.Lesion's diameter,MRI features and the apparent diffusion coefficient(ADC)of the solid part of lesion showed on DWI were compared between malignant PNST(MPNST,n=31)and benign PNST(BPNST,n=88).The receiver operating characteristic curves were drawn for evaluating the value of ADC in the solid part of lesion for distinguishing benign and malignant PNST.Results The diameter of MPNST lesions were larger than that of BPNST,and the proportion of uneven signal on T1WI and T2WI,irregular shape,intratumoral bleeding and cystic changes,unclear margins,peritumoral edema and bone destruction in MPNST were all higher than those in BPNST(all P＜0.05),whereas the proportion of fat division sign,fat ring sign,target sign and bone remodeling were all lower than that in BPNST(all P＜0.05).ADC of the solid components of lesions were obtained in 12 MPNST and 27 BPNST,and both the minimum and the average ADC in MPNST were lower than those in BPNST(both P＜0.05).Taken 1.27× 10-3 mm2/s and 1.38× 10-3 mm2/s as the cutoff value of the minimum ADC and the average ADC,respectively,the area under the curve(AUC)for distinguishing benign and malignant PNST was 0.765 and 0.755,respectively.Conclusion MRI and DWI manifestations of benign and malignant PNST were different to a certain extent.Lesion's diameter,shape,signal characteristics,ADC of the solid component,and perilesional alterations were helpful for differential diagnosis.
万方数据
维普
