CT findings of spleen for predicting differentiation degree of advanced gastric adenocarcinoma
Objective To explore the value of CT finding of spleen for predicting differentiation degrees of advanced gastric adenocarcinoma.Methods Data of 182 patients with advanced gastric adenocarcinoma confirmed by pathology were retrospectively analyzed.The patients were divided into poorly differentiation group(n=89)and moderate-well differentiation group(n=93)according to pathological results.Clinical data and CT finding of both tumor and spleen were compared between groups.Multivariate logistic regression analysis was used to screen the independent impact factors of differentiation degrees of advanced gastric adenocarcinoma.Receiver operating characteristic(ROC)curves were drawn,and the area under the curve(AUC)was calculated to evaluate the efficacy of independent impact factors alone and combination for predicting differentiation degrees of advanced gastric adenocarcinoma.Results Significant differences of patients'age,gender,tumor thickness,tumor maximum diameter,Borrmann classification,clinical T(cT)stage,clinical N(cN)state,clinical TNM(cTNM)stage and splenic CT value on arterial phase were found between poorly differentiation group and moderate-well differentiation group(all P＜0.05).Multivariate logistic regression analysis revealed that patients'age,gender,Borrmann classification,cT stage,cTNM stage and splenic CT value in arterial phase were all independent impact factors of differentiation degrees of advanced gastric adenocarcinoma.AUC of above independent impact factors alone and combination for differentiation degrees of advanced gastric adenocarcinoma was 0.639,0.577,0.621,0.690,0.714,0.606 and 0.861,respectively.Conclusion CT finding of spleen could be used to predict differentiation degrees of advanced gastric adenocarcinoma,and arterial phase splenic CT value was an useful indicator.Combination of clinical and CT findings might improve the predictive efficacy.
万方数据
维普
