Liver,spleen and lumbar R2*values for evaluating iron content in patients with chronic kidney failure
Objective To observe the value of liver,spleen and lumbar R2*values for evaluating iron content in patients with chronic kidney failure(CKD).Methods Totally 52 CKD patients were retrospectively enrolled and divided into absolute iron deficiency group(n=22)or non absolute iron deficiency group(n=30)based on transferrin saturation≤20％or not.Based on modified Dixon quantification(mDIXON-quant)MRI,liver,spleen and lumbar R2*values were compared between groups,and the correlations between the above R2*values and iron metabolism parameters were analyzed.Logistic regression analysis was performed,the influencing factors of absolute iron deficiency and the diagnostic efficiency were analyzed.Results There were significant differences of spleen and lumbar R2*values between absolute iron deficiency group and non absolute iron deficiency group(both P＜0.05).The spleen and lumbar R2*values in CKD patients were positively correlated with ferritin and transferrin saturation(all P＜0.05),negatively correlated with unsaturated iron binding force,total iron binding force and transferrin(all P＜0.05).The lumbar R2*value decreased was an influencing factor of absolute iron deficiency in CKD patients(P＜0.05).Taken lumbar R2*value=134.26 Hz as the best cutoff value,the sensitivity,specificity and the area under the curve for diagnosing absolute iron deficiency in CKD patients was 86.70％,68.20％and 0.727,respectively.Conclusion Lumbar R2*value was helpful for evaluating iron content in CKD patients.
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