Multi-parametric MRI texture analysis for predicting early femoral head necrosis in patients with rectal cancer after radiotherapy
Objective To investigate the value of multi-parametric MRI(mpMRI)texture analysis for predicting early femoral head necrosis(FHN)in rectal cancer patients after radiotherapy.Methods Pelvic MRI of 52 rectal cancer patients who underwent pelvic radiotherapy within 2 weeks before and 3 months after radiotherapy were retrospectively analyzed.Among 52 cases,21 had early FHN(16 cases of stage Ⅰ and 5 cases of stage Ⅱ)but 31 cases had not.Based on T1WI,T2WI and DWI,3D-slicer software was used to segment right femoral head and extract its texture parameters.The texture parameters were compared before and after radiotherapy.Before radiotherapy texture parameters being significant different with those after radiotherapy were included in multivariate logistic regression analysis,and then modelT1WI,modelT2WI,modelDWIand modelTiWI+T2WI+DWI were established.Association Research Circulation Osseous(ARCO)staging of femoral head necrosis was performed after radiotherapy according to imaging findings.Receiver operating characteristic(ROC)curve was used to analyze the efficacy of each single texture parameter and combined model for predicting early FHN in rectal cancer patients after radiotherapy.Results Among T1WI and T2WI texture parameters,the energy and uniformity of femoral head before radiotherapy were higher than those after radiotherapy,while among diffusion weighted imaging texture parameters,the energy of femoral head before radiotherapy was higher than that after radiotherapy,and the long run high gray level emphasis and short run low gray level emphasis were lower than those after radiotherapy.The area under the curve(AUC)of the above pre-radiotherapy texture parameters for predicting early FHN in rectal cancer patients after radiotherapy were 0.581-0.712,and of modelT1WI,modelT2WI and modelDWI modelT1WI+T2WI+DWI was 0.660,0.713,0.770 and 0.853,respectively.Conclusion mpMRI texture parameters could effectively predict early femoral head necrosis in patients with rectal cancer after radiotherapy.
rectal neoplasmsradiotherapyfemur head necrosismagnetic resonance imaging
万方数据
维普
