Ultrasonic features of benign and malignant intraductal papillary mucinous neoplasm of pancreas
Objective To observe two dimensional ultrasound and contrast-enhanced ultrasound(CEUS)characteristics of benign and malignant intraductal papillary mucinous neoplasm(IPMN)of pancreas.Methods Clinical data,two dimensional ultrasound and CEUS features of 15 patients with benign IPMN(benign group)and 11 patients with malignant IPMN(malignant group)were retrospectively comparatively analyzed and compared with MRI/CT features.Results The proportion of patients with elevated carbohydrate antigen 19-9(CA19-9)level and clinical symptoms in malignant group were both higher than those in benign group(both P<0.05).The size of lesions and the proportion of solid components showed on ultrasound in malignant group were higher than those in benign group(both P<0.05),and the main pancreatic duct slightly enlarged in malignant group.CEUS could clearly display dilated pancreatic duct,accurately distinguish mucus thrombi from solid components of tumor,and describe blood supply characteristics of the lesion and internal partitions of lesions not clearly showed on MRI/CT.MRI/CT were able to display some features not clearly showed on ultrasound,such as mural solid components,tumor-surrounding vessels,dilated pancreatic duct,and duct linked to lesions.Conclusion Clinical and ultrasonic features of benign and malignant IPMN were different on some degree.Compared with benign IPMN,patients with malignant IPMN tended to have higher CA19-9 level and clinical symptoms,with larger lesions and more solid components within lesions.