Ultrasound-guided percutaneous biopsy for diagnosing solid pancreatic lesions
Objective To observe diagnostic efficacy of ultrasound-guided percutaneous biopsy for solid pancreatic lesions,also to explore the impact factors of diagnostic accuracy.Methods Data of 746 patients with solid pancreatic lesions underwent ultrasound-guided core needle biopsy(US-CNB)were retrospectively analyzed.Clinical data,imaging records,pancreatic puncture-related information and pathological diagnosis details were collected.After 12 months follow-up,the final clinical diagnoses were assessed,and the efficacy of US-CNB for diagnosing solid pancreatic lesions was evaluated.Univariate analysis and logistic regression analysis were used to screen impact factors for US-CNB diagnostic accuracy of solid pancreatic lesions.Results US-CNB was successfully performed in 742 cases,with the technical success rate of 99.46％(742/746).US-CNB accurately diagnosed pancreatic lesions in 706 cases(accurate group)but inaccurately judged 36 cases(inaccurate group).The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of US-CNB for diagnosing solid pancreatic lesions was 95.25％(702/737),80.00％(4/5),95.15％(706/742),99.86％(702/703)and 10.26％(4/39),respectively.Mild post-procedural complications occurred in 31 cases(31/742,4.18％),while severe complications observed in 4 cases(4/742,0.54％).There were significant differences of patients'age and the ratio of lesions with the maximum diameter＜2 cm,with unclear boundaries or located in the head of pancreas between groups(all P＜0.1).Regression analysis showed that the maximum diameter of lesion＜2 cm was the independent impact factor of the accuracy of US-CNB for diagnosing solid pancreatic lesions(OR=3.054,P=0.030).Conclusion Ultrasound-guided percutaneous biopsy of solid pancreatic lesion was safe and reliable,but its accuracy might decrease in small size lesions.
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