MAGiC technique for diagnosing neonatal hyperbilirubinemia
Objective To observe the value of MAGiC technique for diagnosing neonatal hyperbilirubinemia(NHB).Methods Thirty-three newborns with NHB were prospectively enrolled as NHB group,while 30 healthy newborns were taken as control group.Brain MAGiC MRI were acquired.The quantitative values,including T1,T2 and proton density(PD)values in ROI of the globus pallidus,putamen,and thalamus were recorded,and the ratio of globus pallidus/putamen were calculated.The outcomes in each brain region were compared between groups.Receiver operating characteristic curves were drawn,the areas under the curve(AUC)were calculated to assess diagnostic efficacies,and Pearson analysis were performed to explore correlations of total serum bilirubin(TSB)level with the above quantitative values and quantitative ratios in each brain region.Results No significant difference of T1,T2 nor PD value of each brain region was observed between groups(all P＞0.05),while globus pallidus/putamen T1 ratio and T2 ratio in NHB group were both smaller than those in control group(both P＜0.05).AUC of globus pallidus/putamen T1 ratio for diagnosing NHB was 0.79(P＜0.05),and efficacy of globus pallidus/putamen T2 ratio for diagnosing NHB was insufficient(AUC=0.63,P＞0.05).Negative correlations were observed between TSB and globus pallidus T2 value(r=-0.299,P＜0.05),between TSB and the globus pallidus/putamen T1 ratio(r=-0.480,P＜0.05),also between TSB and the globus pallidus/putamen T2 ratio(r=-0.328,P＜0.05).Conclusion Using MAGiC technology to obtain globus pallidus/putamen T1 ratio was valuable for diagnosis of NHB.
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