Dynamic nomogram based on one-stop whole brain CT perfusion for predicting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
Objective To explore the value of dynamic nomogram based on one-stop whole brain CT perfusion(CTP)for predicting delayed cerebral ischemia(DCI)after aneurysmal subarachnoid hemorrhage(aSAH).Methods Totally 233 aSAH patients were prospectively enrolled,and one-stop whole brain CTP examinations were performed.The patients were randomly divided into training set(n=164)or validation set(n=69)at a ratio of 7:3,and further assigned into subgroups according to whether DCI occurred or not after aSAH.Univariate analysis,linear diagnosis and multivariate logistic regression were used to screen the independent factors for predicting DCI after aSAH,and a traditional nomogram was established,then a dynamic nomogram was constructed based on network.Receiver operating characteristic(ROC)curve was drawn to evaluate the efficacy of the dynamic nomogram for predicting DCI after aSAH.Results Hypertension X mean time to start(mTTS),World Federation of Neurosurgical Societies(WFNS)grade,modified Fisher scale(mFS),and mean flow extraction product(mFEP)were all independent predictors of DCI after aSAH.The sensitivity,specificity and area under the curve(AUC)of the dynamic nomogram for predicting DCI after aSAH was 70.00％,89.50％and 0.890 in training set,76.20％,83.33％and 0.870 in validation set,respectively.Conclusion Dynamic nomogram based on one-stop whole brain CTP could be used to effectively predict DCI after aSAH.
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