摘要
目的 采用meta分析评估68Ga-成纤维细胞活化蛋白抑制剂(FAPI)PET与18F-FDGPET显像诊断胃肠道恶性肿瘤及其转移灶的价值.方法 检索并筛选PubMed、Embase、Web of Science和Cochrane Library自建库至2023年4月11日收录的关于对比68Ga-FAPI PET与18F-FDGPET显像诊断胃肠道恶性肿瘤及转移价值的文献并提取相关数据,以Stata 16.0及Review Manager 5.3.5软件进行数据分析.结果 共纳入9篇文献、370例胃肠道恶性肿瘤患者,其中62例伴淋巴转移、29例伴肝转移、17例伴骨转移、50例伴腹膜转移.68Ga-FAPI PET显像在患者及病灶层面诊断胃肠道恶性肿瘤原发灶、淋巴结转移及腹膜转移的敏感度均高于18F-FDG PET(P均＜0.05),而二者在患者层面诊断骨转移及肝转移敏感度差异均无统计学意义(P均＞0.05).结论 68Ga-FAPI PET显像诊断胃肠道恶性肿瘤及转移的价值优于18F-FDG PET.
Abstract
Objective To observe the value of 68Ga-fibroblast activation protein inhibitor(FAPI)PET and 18F-FDG PET imaging for diagnosing gastrointestinal malignant tumors and metastases using meta-analysis.Methods Literature about comparison on the value of 68Ga-FAPI PET and 18F-FDG PET imaging for diagnosing gastrointestinal malignancies and metastases were searched in PubMed,Embase,Web of Science and Cochrane Library from the establishment of database to April 11,2023 and then screened,and the relevant data were extracted and analyzed using Stata 16.0 and Review Manager 5.3.5.Results Totally 9 articles mentioned 370 patients with gastrointestinal malignant tumors were enrolled,including 62 cases with lymphatic metastasis,29 with liver metastasis,17 with bone metastasis and 50 with peritoneal metastasis.The sensitivity of 68Ga-FAPI PET imaging for diagnosing primary lesion,lymph node metastasis and peritoneal metastasis of gastrointestinal malignant tumors were all higher than that of 18F-FDG PET imaging on both patient and lesion level(all P＜0.05),but no significant difference of these 2 methods for diagnosing bone metastasis nor liver metastasis was found on patient level(both P＞0.05).Conclusion The value of 68Ga-FAPI PET imaging for diagnosing gastrointestinal malignant tumors and metastases was superior to 18F-FDG PET imaging.
基金项目
省部共建放射医学与辐射防护国家重点实验室开放基金(GZK1202243)
苏州市科技发展项目(SKY2022156)
NETL
NSTL
万方数据