68Ga-FAPI PET and 18F-FDG PET imaging for diagnosing gastrointestinal malignant tumors and metastases:Meta-analysis
Objective To observe the value of 68Ga-fibroblast activation protein inhibitor(FAPI)PET and 18F-FDG PET imaging for diagnosing gastrointestinal malignant tumors and metastases using meta-analysis.Methods Literature about comparison on the value of 68Ga-FAPI PET and 18F-FDG PET imaging for diagnosing gastrointestinal malignancies and metastases were searched in PubMed,Embase,Web of Science and Cochrane Library from the establishment of database to April 11,2023 and then screened,and the relevant data were extracted and analyzed using Stata 16.0 and Review Manager 5.3.5.Results Totally 9 articles mentioned 370 patients with gastrointestinal malignant tumors were enrolled,including 62 cases with lymphatic metastasis,29 with liver metastasis,17 with bone metastasis and 50 with peritoneal metastasis.The sensitivity of 68Ga-FAPI PET imaging for diagnosing primary lesion,lymph node metastasis and peritoneal metastasis of gastrointestinal malignant tumors were all higher than that of 18F-FDG PET imaging on both patient and lesion level(all P＜0.05),but no significant difference of these 2 methods for diagnosing bone metastasis nor liver metastasis was found on patient level(both P＞0.05).Conclusion The value of 68Ga-FAPI PET imaging for diagnosing gastrointestinal malignant tumors and metastases was superior to 18F-FDG PET imaging.
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