Changes of static and dynamic functional connectivity of default mode network in patients with major depressive disorder
Objective To explore changes of static and dynamic functional connectivity of default mode network(DMN)in patients with major depressive disorder(MDD)based on resting-state functional MRI(rs-fMRI).Methods Brain high-resolution structural MRI and rs-fMRI data of 55 MDD patients(MDD group)and 35 healthy subjects(control group)were retrospectively analyzed.Pre-processing and group independent component analysis(ICA)were performed to extract DMN using CONN toolbox running on the Matlab.Static and dynamic changes of functional connectivity of DMN and whole brain were compared between groups.Pearson correlation analysis was used to explore correlations of DMN in MDD group being different functional connectivity compared with control group and scores of Hamilton depression scale-24(HAMD-24),Hamilton anxiety scale(HAMA)and Wechsler intelligence test.Results Compared with control group,static functional connectivity of DMN over thalamus,precuneus and precentral gyrus in MDD group were weakened(all P＜0.05),while functional connectivity strength between DMN and thalamus was lowly negatively correlated with HAMD-24 scores(r=-0.333,P=0.014).Compared with control group,dynamic functional connectivity between both medial prefrontal cortex and left/right lateral parietal lobe of DMN and nucleus accumbens,as well as left lateral parietal lobe,posterior cingulate gyrus of DMN and thalamus in MDD group were all weakened.In MDD group,dynamic functional connectivity strength of medial prefrontal cortex-nucleus accumbens and posterior cingulate gyrus-thalamus of DMN were both lowly positively correlated with HAMD-24 scores(r=0.313,P=0.019;r=0.311,P=0.021).Conclusion MDD patients had abnormal static and dynamic functional connectivity of DMN and other brain regions,some were associated with the severity of depressive disorder.
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