摘要
目的 构建基于前列腺多参数MRI(mpMRI)自动甄别其主要扫描序列的3D ResNet深度学习模型,并评估其价值.方法 收集于3个医疗中心接受超声引导下前列腺穿刺的1 086例患者穿刺前1 153次前列腺mpMRI资料,并按不同扫描序列加以拆分,分别将T2WI、弥散加权成像(DWI)及表观弥散系数(ADC)图归入相应数据集,共获得5 151组图像,并将归类为非脂肪抑制T2WI(T2WI_nan,n=1 000)、脂肪抑制T2WI(T2WI_fs,n=1 188)、高b值DWI(DWI_High,b 值 ≥500 s/mm2,n=1 045)、低 b 值 DWI(DWI_Low,b 值＜500 s/mm2,n=1 012)及 ADC 图(ADC map,n=906).按8∶1∶1比例将全部图像分为训练集(n=4 122)、验证集(n=513)和测试集(n=516).行预处理及扩增后,采用3D ResNet于训练集及验证集训练及优化自动甄别图像类别模型,以测试集评估模型分类效能.结果 所获模型分类测试集不同序列图像的准确率、敏感度、特异度、阳性预测值、阴性预测值、F1值及Kappa值分别为0.995～1.000、0.990～1.000、0.998～1.000、0.990～1.000、0.998～1.000、0.995～1000、0.994～1.000.结论 3D ResNet 深度学习模型能有效自动甄别前列腺mpMRI所涉主要扫描序列.
Abstract
Objective To construct a 3D ResNet deep learning model based on multi-parametric prostate MRI(mpMRI),and to observe its value for automatically identifying the main MR sequences.Methods Totally 1 153 sets pre-biopsy prostate mpMRI data of 1 086 patients who underwent ultrasound-guided prostate biopsy in 3 hospitals were collected and divided into different image datasets,i.e.T2WI,diffusion-weighted imaging(DWI)and apparent diffusion coefficient(ADC)maps with a total of 5 151 images.Then the images were categorized into non-fat-suppressed T2WI(T2WI_nan,n=1 000),fat-suppressed T2WI(T2WI_fs,n=1 188),high b-value DWI(DWI_High,b-value≥500 s/mm2,n=1 045),low b-value DWI(DWI_Low,b-value＜500 s/mm2,n=1 012)or ADC map(n=906),also divided into training set(n=4 122),verification set(n=513)and test set(n=516)at the ratio of 8∶1∶1.After preprocessing and augmentation,a 3D ResNet model for automatically identifying image categories was trained and optimized in the training and verification sets,and its classification efficiency was evaluated in the test set.Results The identifying accuracy,sensitivity,specificity,positive predictive value,negative predictive value,F1 score and Kappa value of the obtained model for automatically identifying categories of images in the test set was 0.995-1.000,0.990-1.000,0.998-1.000,0.990-1.000,0.998-1.000,0.995-1.000 and 0.994-1.000,respectively.Conclusion The obtained 3D ResNet deep learning model could effectively and automatically identify the main sequences of prostate mpMRI.
维普
万方数据