Intravoxel incoherent motion MRI for predicting isocitrate dehydrogenase and 1p/19q molecular type of glioma
Objective To observe the value of intravoxel incoherent motion(IVIM)MRI for predicting isocitrate dehydrogenase(IDH)and 1p/19q molecular type of glioma.Methods Data of 32 patients with gliomas were retrospectively analyzed.The patients were divided into IDH mutation group(n=18)and wild group(n=14)based on IDH detection results,and those in mutation group were further divided into lp/19q co deletion subgroup(n=5)and non co deletion subgroup(n=13)based on chromosome 1p/19q detection results.General information and IVIM parameters,including apparent diffusion coefficient(ADC),slow diffusion coefficient(D),fast diffusion coefficient(D*),perfusion fraction(f),relative ADC(rADC),relative D(rD),relative D*(rD*)and relative f(rf)values were compared between groups and subgroups,and the effectiveness of the above parameters for predicting molecular type of gliomas were analyzed.Results Patients'age in mutation group was younger than that in wild group(t=-4.274,P=0.001).ADC,rADC and D values of mutant group were all higher,while D*and rf values were both lower than those of wild group(all P＜0.05),and the area under the curve(AUC)of ADC,rADC,D,D*and rf values for predicting IDH type of glioma was 0.80,0.76,0.74,0.78 and 0.72,respectively.D*value in co deletion subgroup was greater than that in non co deletion subgroup(P＜0.05),with AUC for predicting 1p/19q type of IDH mutant glioma of 0.88.Conclusion ADC,rADC,D,D*and rf values of glioma were all helpful for predicting IDH mutations,and D*value was also helpful for predicting chromosome 1p/19q co deletion.
NETL
NSTL
万方数据
