Three-dimensional ultrasound parameters of carotid atherosclerotic plaque for evaluating risk of coronary heart disease in patients with type 2 diabetes mellitus
Objective To observe the value of three-dimensional(3D)ultrasound volumetric parameters of carotid atherosclerotic plaque for evaluating the risk of coronary heart disease(CHD)in patients with type 2 diabetes mellitus(T2DM).Methods Totally 88 T2DM patients with carotid atherosclerotic plaque were prospectively enrolled and divided into CHD group(n=56)and non-CHD group(n=32)according to results of coronary artery angiography.Clinical data,two-dimensional(2D)and 3D ultrasonic findings of carotid atherosclerotic plaques were collected and compared between groups.The independent predictors of CHD in T2DM patients were screened with multivariate logistic regression.Then the receiver operating characteristic curves of 3D volumetric parameters of carotid atherosclerotic plaque were drawn,the areas under the curve(AUC)were calculated,and efficacy for predicting the risk of CHD in T2DM patients were evaluated and compared.Results Compared with patients in non-CHD group,T2DM patients in CHD group had longer diabetes duration,higher glycosylated hemoglobin and low density lipoprotein(LDL),as well as bigger carotid atherosclerotic plaque volume and lower grayscale median(GSM)(all P＜0.05).Along with diabetes duration and LDL,the volume and GSM of carotid atherosclerotic plaque were also the predictive factors for CHD in T2DM patients(all P＜0.05).AUC of volume and GSM of carotid atherosclerotic plaque and the combination of them was 0.864,0.828 and 0.927,respectively,and of the combination was higher than each alone(all P＜0.05).Conclusion The volume and GSM of carotid atherosclerotic plaque obtained with 3D ultrasound could indirectly reflect the risk of CHD in T2DM patients.Combination of these two parameters was more effective for predicting the risk of CHD.
万方数据
维普
