摘要
目的 观察非酒精性脂肪性肝病(NAFLD)定量非对称回波最小二乘估算法迭代水脂分离序列(IDEAL-IQ)脂肪参数与临床资料的相关性.方法 前瞻性纳入42例NAFLD患者,根据体质量指数分为瘦型组(n=9)、超重组(n=19)及肥胖组(n=14);比较3组间及两两组间临床资料及IDEAL-IQ脂肪参数[即肝脏脂肪分数(HFF)、腹部内脏脂肪组织(VAT)体积及皮下脂肪组织(SAT)体积],分析HFF、腹部VAT及SAT体积与临床资料的相关性.结果 3组腹部VAT及SAT体积差异均有统计学意义(P均＜0.05);其中,肥胖组腹部VAT体积明显高于瘦型组及超重组,两两组间比较腹部SAT体积差异均有统计学意义(P均＜0.05).男性与女性患者腹部VAT及SAT体积差异均有统计学意义(t=2.559、2.606,P均＜0.05),而HFF差异无统计学意义(t=1.332,P=0.191).NAFLD患者HFF与年龄、收缩压(SBP)、舒张压(DBP)及谷草转氨酶(GOT)均呈正相关(r=0.418、0.408、0.370、0.340,P 均＜0.05).结论 NAFLD 患者HFF与年龄、SBP、DBP及AST相关,腹部VAT及SAT体积与性别相关.
Abstract
Objective To observe the correlations of iterative decomposition of water and fat with echo asymmetry and the least squares estimation quantification sequence(IDEAL-IQ)fat parameters and clinical data in patients with non-alcoholic fatty liver disease(NAFLD).Methods Totally 42 NAFLD patients were prospectively enrolled and divided into lean group(n=9),overweight group(n=19)and obese group(n=14)based on body mass index.Clinical data and IDEAL-IQ fat parameters(hepatic fat fraction[HFF],abdominal visceral adipose tissue[VAT]and subcutaneous adipose tissue[SAT]volumes)were compared among 3 groups and between each 2 groups,and the correlations of HFF,abdominal VAT and SAT volumes and clinical data were analyzed.Results Significant differences of abdominal VAT and SAT volumes were found among 3 groups(both P＜0.05).Abdominal VAT volume in obese group was significantly higher than that in lean and overweight groups(both P＜0.05),and significant differences of abdominal SAT volume were found between each 2 groups(all P＜0.05).Meanwhile,significant differences of abdominal VAT and SAT volumes were found between male and female patients(t=2.559,-2.606,both P＜0.05),but not of HFF(t=1.332,P=0.191).HFF was positively correlated with age,systolic blood pressure(SBP),diastolic blood pressure(DBP)and glutamic-oxaloacetic transaminase(GOT)in NAFLD patients(r=0.418,0.408,0.370,0.340,all P＜0.05).Conclusion In NAFLD patients,HFF was related to age,SBP,DBP and GOT,while abdominal VAT and SAT volumes were related to gender.
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