全肿瘤表观弥散系数直方图鉴别腺泡状软组织肉瘤组织学级别
Whole-tumor apparent diffusion coefficient histogram for identifying histological grade of alveolar soft part sarcoma
孟帆 1袁军辉 2张孝先 2方少伯 3郭兰伟 4单东秋 2陈学军2
作者信息
- 1. 郑州大学附属肿瘤医院/河南省肿瘤医院医学影像科,河南郑州 450008;福建医科大学附属协和医院医学影像科,福建 福州 350005
- 2. 郑州大学附属肿瘤医院/河南省肿瘤医院医学影像科,河南郑州 450008
- 3. 郑州大学人民医院/河南省人民医院影像科,河南郑州 450008
- 4. 郑州大学附属肿瘤医院/河南省肿瘤医院肿瘤防治研究办公室,河南郑州 450008
- 折叠
摘要
目的 观察全肿瘤表观弥散系数(ADC)直方图鉴别腺泡状软组织肉瘤(ASPS)病理组织学级别的价值.方法 回顾性分析43例ASPS、包括高级别组27例和低级别组16例,记录患者生存资料,分析肿瘤MRI表现,获取全肿瘤ADC直方图参数并进行组间比较,评估组间差异有统计学意义参数与组织学分级结果的相关性,评估其鉴别高、低级别ASPS的效能.结果 低级别组患者5年生存率为82.05％,高于高级别组的51.28％(P＜0.05).与低级别组相比,高级别组远处转移、ASPS肿瘤≥5 cm,以及伴瘤周水肿、肿瘤内分隔等特征者占比均较高(P均＜0.05).全肿瘤ADC直方图参数中,高级别组5th、10th、25th、50th、75th、90th及均值均低于低级别组(P均＜0.05),且均与肿瘤病理组织学分级呈负相关(-0.547～-0.385,P均＜0.05),其鉴别高、低组织学分级ASPS的受试者工作特征曲线下面积为0.734～0.822,鉴别效能均较好.结论 全肿瘤ADC直方图参数可较为有效地鉴别高、低级别ASPS.
Abstract
Objective To observe the value of whole-tumor apparent diffusion coefficient(ADC)histogram for identifying histopathological grade of alveolar soft part sarcoma(ASPS).Methods Forty-three ASPS patients,including 27 cases of high-grade ASPS(high-grade group)and 16 cases of low-grade ASPS(low-grade group)were retrospectively enrolled.Patients'survival data were collected,MRI manifestations of ASPS were recorded,and the whole-tumor ADC histogram parameters were obtained and compared between groups.The correlations of whole-tumor ADC histogram parameters being different between groups with tumors'histological grading were analyzed,and the efficacy of whole-tumor ADC histogram parameters for identifying high-grade and low-grade ASPS were assessed.Results The 5-year survival rate of ASPS patients in low-grade group was 82.05％,higher than that(51.28％)in high-grade group(P＜0.05).The percentage of distant metastasis,tumor≥5 cm,as well as of tumors with features such as peritumoral edema and intra-tumoral septum in high-grade group were all higher than in low-grade group(all P＜0.05).The 5th,10th,25th,50th,75th,90th and the mean values of ADC in high-grade group were all lower than those in low-grade group(all P＜0.05)and negatively correlated with pathohistological grade of ASPS(from-0.547 to-0.385,all P＜0.05).The aeras under the receiver operating characteristic curves of the above parameters ranged from 0.734 to 0.822,which were fairly good for identifying high-grade and low-grade ASPS.Conclusion Whole-tumor ADC histogram parameters could be used to effectively identify high-grade and low-grade ASPS.
关键词
肉瘤,软组织腺泡状/间变/磁共振成像Key words
sarcoma,alveolar soft part/anaplasia/magnetic resonance imaging引用本文复制引用
出版年
2024
NETL
NSTL
万方数据