68Ga-FAPI PET/CT及PET/MR诊断恶性肿瘤研究进展
Research progresses of 68Ga-FAPI PET/CT and PET/MR for diagnosing malignant tumors
李天悦 1马拓 1赵新明 1张召奇 1王建方 1戴萌 1赵秀娟 1张敬勉1
作者信息
- 1. 河北医科大学第四医院核医学科,河北 石家庄 050011
- 折叠
摘要
成纤维细胞激活蛋白抑制剂(FAPI)可与肿瘤间质内高表达的成纤维细胞激活蛋白特异性结合;68Ga-FAPI不参与肿瘤细胞葡萄糖代谢.68Ga-FAPI PET/CT及PET/MR可用于多部位恶性肿瘤显像,对于诊断与鉴别诊断具有独特优势.本文围绕68Ga-FAPI PET/CT及PET/MR诊断恶性肿瘤研究进展进行综述.
Abstract
Fibroblast activation protein inhibitors(FAPI)can specifically bind to fibroblast activation protein,which is highly expressed in tumor stroma,and 68Ga-FAPI do not get involved into the procedure of glucose metabolism in tumor cells.68Ga-FAPI PET/CT and PET/MR can be used for displaying malignant tumors at various sites and play a unique role for diagnosis and differential diagnosis.The research progresses of 68 Ga-FAPI-based PET/CT and PET/MR for diagnosing malignant tumors were reviewed in this article.
关键词
肿瘤/镓放射性同位素/正电子发射断层显像术/体层摄影术,X线计算机/磁共振成像Key words
neoplasms/gallium radioisotopes/positron-emission tomography/tomography,X-ray computed/magnetic resonance imaging引用本文复制引用
出版年
2024
NETL
NSTL
万方数据