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山楂叶总黄酮缓释片的制备及Beagle犬体内外相关性研究

Preparation and in vitro-in vivo Correlation in Beagle Dogs of Hawthorn Leaves Flavonoids Sustained-release Tablets

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以山楂叶总黄酮为模型药物,羟丙甲纤维素(HPMC)、乙基纤维素(EC)及丙烯酸树脂(Eudragit L100)为混合骨架材料制备日服两次的缓释片,以牡荆素为指标成分,考察Beagle犬单剂量Lj服缓释片后的药代动力学特征.结果表明,本品缓释特征较好,体外释放较符合WeibuU模型,本品体外释放度与Beagle犬体内药物吸收分数之间相关系数为0.98.
Twice a day sustained-release tablets were developed for the Hawthorn leaves flavonoids, using hydroxypropyl methylcellulose (HPMC), ethylcellulose (EC) and Eudragit L100 as combined matrix materials. Pharmacokinetics of the tablets were investigated in Beagle dogs with vitexin as marker compound. Results showed that the prepared tablets possessed a good sustained-release characteristic. Weibull model was the optimal model for the description of drug release profile. The correlation coefficient between the fraction of absorption in vivo and the release rate in vitro was 0.98.

Hawthorn leaves flavonoidssustained-release tabletin vitro releasein vitro-in vivo correlation

黄平、何春柏、赵子明、唐翠

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复旦大学生命科学学院遗传工程重点实验室,上海,200433

复旦大学药学院药剂系,上海,201203

山楂叶总黄酮 缓释片 体外释放 体内外相关性

2009

中国医药工业杂志
上海医药工业研究院,中国化学制药工业协会

中国医药工业杂志

CSTPCDCSCD北大核心
影响因子：0.487
ISSN：1001-8255
年,卷(期)：2009.40(8)
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