仿生纳米载体提高口服药物生物利用度的研究进展
Research Progress of Biomimetic Nanocarriers in Improving Bioavailability of Oral Drugs
安秋旭 1霍代夏 1刘媛媛 1吕晓洁1
作者信息
- 1. 内蒙古医科大学药学院,内蒙古呼和浩特 010000
- 折叠
摘要
口服给药是首选的给药方法,但由于药物自身独特的性质和胃肠道屏障,口服给药的生物利用度受到限制.参考自然界存在生物体的结构特性,从仿生学角度出发,设计、制备的仿生载体可以改善药物的口服吸收,具有良好发展前景.该文综述了基于不同仿生思路设计及制备的纳米载体在口服给药中的应用,为口服纳米载体的开发提供了思路,也为口服纳米载体应用于临床提供了参考.
Abstract
Oral administration is the preferred method for drug delivery.However,due to the unique properties of drugs and the gastrointestinal barrier,the bioavailability of oral administration is limited.By referencing the structural characteristics of organisms in nature and adopting a biomimetic perspective,the biomimetic nanocarriers can be designed and prepared to improve the oral absorption of drugs,which hold promising development prospects.This review summarizes the application of nanocarriers designed and prepared with various biomimetic ideas in oral drug delivery,offering insights and references for the development and clinical application of oral nanocarriers.
关键词
纳米载体/口服给药/生物利用度/仿生设计Key words
nanocarrier/oral adiministration/bioavailability/bionic design引用本文复制引用
基金项目
内蒙古医科大学面上项目(YKDMS2022MS028)
出版年
2023
NETL
NSTL
维普
万方数据