血清白蛋白-紫杉醇纳米粒的研究进展
Research Progress of Serum Albumin-paclitaxel Nanoparticles
黄梦玲 1阮海华 1宋芸2
作者信息
- 1. 天津商业大学生物技术与食品科学学院,天津市食品生物技术重点实验室,天津 300134
- 2. 海南医学院海南省热带药用植物研发重点实验室,海南海口 571199
- 折叠
摘要
紫杉醇属于二萜类化合物,对卵巢癌、乳腺癌等多种恶性肿瘤具有良好的抗肿瘤活性.紫杉醇因难溶于水,直接用药后不良反应较大,应用受到限制.血清白蛋白纳米粒可弥补药物本身的缺陷,通过增强药物在体内的稳定性、提高生物利用度和靶向性来达到增效、减毒的目的,一定程度上可解决紫杉醇的问题.该文综述了血清白蛋白-紫杉醇纳米粒的制备工艺、修饰血清白蛋白在载紫杉醇纳米粒中的应用,以期为研发满足临床实际应用的血清白蛋白纳米载药系统提供理论指导.
Abstract
Paclitaxel belongs to the diterpenoid compounds and has good antitumor activity against various cancers such as ovarian cancer and breast cancer.Due to its poor solubility,paclitaxel has significant adverse reactions when it was used directly,limiting its clinical application.Serum albumin nanoparticles can compensate for the inherent defects of paclitaxel,enhance the stability of the drug in the body,improve its bioavailability and targeting ability,achieve the purpose of enhancing efficacy and reducing toxicity,and to some extent solve the problem of paclitaxel.This review summarizes the preparation process of serum albumin-paclitaxel nanoparticles,the application of modified serum albumin in paclitaxel-loaded nanoparticles,in order to provide theoretical guidance for the development of serum albumin based nanodrug delivery systems that meet actual clinical applications.
关键词
血清白蛋白/紫杉醇/纳米粒/制备工艺/表面修饰Key words
serum albumin/paclitaxel/nanoparticle/preparation process/surface modification引用本文复制引用
出版年
2023
NETL
NSTL
维普
万方数据