透明质酸修饰的脂质体用于经皮给药的研究进展
Research Progress of Hyaluronic Acid Modified Liposomes for Transdermal Drug Delivery
劳杰铿 1杨紫瑜 1林华庆1
作者信息
- 1. 广东药科大学,广东省药物新剂型重点实验室,广东广州 510006
- 折叠
摘要
透明质酸表面修饰的脂质体作为新型脂质体经皮给药载体,可通过透明质酸强大的水化作用使得角质层膨胀,显著提高药物的透皮渗透效果.透明质酸还具有独特结构和肿瘤细胞靶向性,在脂质体表面能形成网状结构,起到主动靶向、防止药物泄露、延长药物释放时间、增加稳定性和协同增强抗肿瘤疗效等作用.本研究主要介绍了透明质酸修饰脂质体的制备方法及相关参数、透明质酸与脂质体的协同透皮吸收、增强脂质体的肿瘤细胞靶向性、修饰后脂质体的稳定性和缓释效果、应用前景等方面的研究进展,为进一步开发透明质酸修饰的脂质体用作经皮给药载体提供参考.
Abstract
Surface modified liposomes with hyaluronic acid as a new transdermal drug delivery carrier can significantly improve the transdermal penetration of drugs by swelling the stratum corneum through the powerful hydration effect of hyaluronic acid.Due to its unique structure and tumor cell targeting,hyaluronic acid forms a mesh structure on the surface of liposomes,which can realize active targeting,prevent drug leakage,prolong drug release,improve stability,and synergistically enhance antitumor activity.This study mainly introduces the research progress of hyaluronic acid modified liposomes in the aspects of the preparation methods and related parameters,synergistic transdermal absorption of hyaluronic acid and liposomes,enhancement of tumor cell targeting of liposomes,the stability and sustained release effect of modified liposomes,as well as application prospects.It provides a reference for the further development of hyaluronic acid modified liposomes for transdermal drug delivery.
关键词
透明质酸/脂质体/经皮给药/主动靶向/抗肿瘤活性Key words
hyaluronic acid/liposome/transdermal drug delivery/active targeting/antitumor activity引用本文复制引用
出版年
2023
NETL
NSTL
维普
万方数据