摘要
阴道给药途径因给药部位血流丰富、面积大,能避免肝首过效应等优势而受到关注,但传统剂型是存在泄露和使用不适等问题.目前已经提出将生物黏附材料、温敏性材料、pH响应性材料、黏膜渗透技术和纳米技术等策略用于改善药物在阴道的滞留时间、渗透性和释放特性.文章结合阴道的生理结构和特点,综述了通过阴道黏膜给药的新型药物制剂递送策略和技术,期望能为阴道局部用药、子宫靶向给药产品的开发提供依据.
Abstract
Vaginal drug delivery has attracted great attention due to its advantages such as rich blood supply,large surface area of vagina and avoidance of the hepatic first-pass effect.However,there are still issues such as leakage and discomfort in application of traditional drug dosage forms for vaginal administration.At present,strategies such as bioadhesive materials,thermosensitive materials,pH responsive materials,mucosal penetration techniques and nano technologies have been proposed to improve the retention time,permeability,and release characteristics of drugs in the vagina.Based on the physiological structure and characteristics of the vagina,this review summarizes the delivery strategies and techniques of drug delivery through the vaginal mucosa,hoping to provide a reference for the development of vaginal topical medication and uterine-targeting delivery products.
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