Research Progress of Nanobiomaterials in Tumor Hypoxia Relief Strategy
Hypoxia,a critical environmental characteristic of advanced solid tumors,not only stimulates the proliferation and metastasis of cancer cells,but also becomes one of the main obstacles in the process of tumor treatment.Consequently,manipulating hypoxia within tumor microenvironment is deemed an effective approach to enhance the success rate of cancer therapy.With the progressions in nanotechnology and material science,nanobiomaterial-assisted oxygen therapy has garnered increasing interest in the field of cancer treatment.This review mainly summarizes three strategies based on nanobiomaterials to alleviate tumor hypoxia according to the oxygen supplementation methods at the tumor sites,namely,the remodeling of the tumor microenvironment(endogenous oxygen supplementation),targeted delivery of nanoscaled oxygen carriers(exogenous oxygen transport),and in situ oxygen catalytic regeneration.It is hoped that this review can provide new ideas for researchers in the study of tumor hypoxia relief.
万方数据
维普
